PMID: 2103491Apr 1, 1990Paper

Biological and clinical significance of cathepsin D in breast cancer

Seminars in Cancer Biology
H Rochefort

Abstract

Cathepsin D is an acidic lysosomal protease present in all cells. In breast cancer cells, pro-cathepsin D expression and secretion are markedly increased and its processing is altered. This protease is induced by estrogens and growth factors. In vitro, pro-cathepsin D is an autocrine mitogen on breast cancer cells and can be auto-activated to degrade extracellular matrix and proteoglycans in acidic microenvironment. In patients, there is a significant correlation between high cathepsin D concentrations in the cytosol of primary breast cancer and development of metastasis. This marker is independent of other prognostic factors and appears to be particularly useful in lymph node-negative tumors. These results suggest that derouting and overexpression of cathepsin D plays an important role in invasion and metastasis of breast cancer cells.

References

Sep 27, 1979·Biochemical and Biophysical Research Communications·B Westley, H Rochefort
Oct 29, 1979·Biochemical and Biophysical Research Communications·W B ButlerT L Jorgensen
Jul 16, 1986·Biochemical and Biophysical Research Communications·M MorissetH Rochefort
Dec 1, 1986·Journal of Clinical Pathology·W A ReidJ Kay
Apr 14, 1980·Biochemical and Biophysical Research Communications·D P EdwardsW L McGuire

❮ Previous
Next ❯

Citations

Aug 1, 1997·Journal of Surgical Oncology·G E TheodoropoulosB C Golematis
Jul 1, 1994·Cancer·E G MansourL Dressler
Mar 1, 1995·Journal of Surgical Oncology·G E TheodoropoulosB C Golematis
Dec 1, 1995·Journal of Surgical Oncology·Y ItohA Masaoka
Dec 1, 1990·Cancer Metastasis Reviews·H RochefortM Garcia
May 1, 1992·Clinical & Experimental Metastasis·M J Duffy
Jan 1, 1994·Breast Cancer Research and Treatment·R B DicksonM D Johnson
Jan 1, 1993·Breast Cancer Research and Treatment·S VeneroniR Silvestrini
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·K M MitchellD Smith
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·W Remmele, J Sauer-Manthey
Jan 1, 1993·Breast Cancer Research and Treatment·P M Ravdin
Apr 1, 1997·Endocrine Pathology·Steven M. Ruhoy, Martha R. Clarke
Jul 9, 1998·Pathology Oncology Research : POR·P AthanassiadouS Michalas
Mar 13, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·M K Schwartz
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M GionS Dante
Jan 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B R Westley, F E May
Sep 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·J G KlijnJ A Foekens
Jul 1, 1991·Trends in Cell Biology·D Goldfarb, N Michaud
Mar 27, 1998·Breast Cancer Research and Treatment·A A Rasmussen, K J Cullen
Mar 5, 1999·Breast Cancer Research and Treatment·I C Henderson, A J Patek
Mar 5, 1999·Breast Cancer Research and Treatment·D G Altman, G H Lyman
Jun 25, 1992·The New England Journal of Medicine·W L McGuire, G M Clark
Jun 21, 2008·Carcinogenesis·Vitalia SagulenkoFrank Westermann
Aug 26, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Clive R Taylor
Oct 9, 1998·Journal of Cutaneous Pathology·H InoueA Ishibashi
Feb 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K Barabasi, L Nässberger
Jan 1, 1991·Annals of the New York Academy of Sciences·A Bluming, W J Hrushesky
Feb 24, 2001·Drug Metabolism and Drug Interactions·S GoldwynH Wei
Sep 21, 2013·Biomarkers in Medicine·Milan MarkićevićDragica Nikolić-Vukosavljević
May 1, 1995·Protein Science : a Publication of the Protein Society·M FujinagaM N James
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E T BaldwinJ W Erickson
Mar 12, 2009·Cancer Research·Ian F RobeyRobert J Gillies

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.