Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation

Cancer Metastasis Reviews
Kenichi SudaTetsuya Mitsudomi

Abstract

KRAS and epidermal growth factor receptor (EGFR) are the two most frequently mutated proto-oncogenes in adenocarcinoma of the lung. The occurrence of these two oncogenic mutations is mutually exclusive, and they exhibit many contrasting characteristics such as clinical background, pathological features of patients harboring each mutation, and prognostic or predictive implications. Lung cancers harboring the EGFR mutations are remarkably sensitive to EGFR tyrosine kinase inhibitors such as gefitinib or erlotinib. This discovery has dramatically changed the clinical treatment of lung cancer in that it almost doubled the duration of survival for lung cancer patients with an EGFR mutation. In this review, we describe the features of KRAS mutations in lung cancer and contrast these with the features of EGFR mutations. Recent strategies to combat lung cancer harboring KRAS mutations are also reviewed.

References

May 1, 1991·Genes, Chromosomes & Cancer·J Whang-PengJ D Minna
Jul 17, 1991·Journal of the National Cancer Institute·R J SlebosS Rodenhuis
Aug 30, 1990·The New England Journal of Medicine·R J SlebosW J Mooi
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P J CaseyJ E Buss
May 1, 1988·Mutation Research·J L Bos
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C J DerG M Cooper
Nov 11, 1982·Nature·C J TabinE H Chang
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K ShimizuM H Wigler
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T G Krontiris, G M Cooper
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·E TsuchiyaH Sugano
Aug 31, 2001·Nature Genetics·Z ZhangM You
Jan 2, 2003·Nature Reviews. Cancer·Julian Downward
May 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Masahiro FukuokaJosé Baselga
Jul 31, 2004·Science·Raffaella SordellaJeffrey Settleman
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Roberto DiazAngel Pellicer
Nov 3, 2004·Trends in Cell Biology·Gretchen A RepaskyChanning J Der
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tetsuya MitsudomiYasushi Yatabe
Mar 3, 2005·Journal of the National Cancer Institute·Hisayuki ShigematsuAdi F Gazdar
Mar 9, 2005·Cancer Research·Hisayuki ShigematsuAdi F Gazdar
May 3, 2005·Nature Reviews. Cancer·Nancy E Hynes, Heidi A Lane
May 5, 2005·Journal of the National Cancer Institute·Federico CappuzzoMarileila Varella-Garcia
Jul 30, 2005·Current Biology : CB·Natalia MitinChanning J Der
Aug 5, 2005·Nature·Manuel ColladoManuel Serrano

❮ Previous
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Citations

Apr 30, 2013·Endocrine Pathology·Ji Young ParkKyoung Sik Park
Jul 3, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Fabio ConfortiTommaso Martino De Pas
Apr 27, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Natasha RekhtmanAndre L Moreira
Dec 21, 2010·Pathology International·Hanako SatoTakuya Yazawa
Dec 1, 2012·Archives of Pathology & Laboratory Medicine·Philip T Cagle, Timothy Craig Allen
Jan 2, 2013·Archives of Pathology & Laboratory Medicine·Philip T Cagle, Randall J Olsen
Jun 1, 2013·Archives of Pathology & Laboratory Medicine·Timothy Craig Allen
Nov 20, 2012·Bioanalysis·Sterghios Athanasios Moschos
Jan 21, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M MacerelliJ C Soria
Jan 21, 2012·Pulmonary Medicine·William DubinskiDavid M Hwang
Feb 19, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Marta Herreros-VillanuevaTze-Kiong Er
Feb 27, 2014·In Vitro Cellular & Developmental Biology. Animal·So-Jung ChoiJhingook Kim
Dec 18, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Howard H WuLiang Cheng
Oct 5, 2014·Current Problems in Cancer·Kevin E FisherMichael R Rossi
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Hong KangMing-Juan Liao
Dec 2, 2015·Experimental and Therapeutic Medicine·Tianyan WangNing Wang
Dec 2, 2015·Oncology Letters·Eirini PapadopoulouGeorge Nasioulas
Dec 2, 2015·Oncology Letters·Junichi SohShinichiro Miyoshi
Jan 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kenichi Suda, Tetsuya Mitsudomi
Oct 19, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Oscar ArrietaUNKNOWN CLICaP
Jan 7, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sunny GuinDan Theodorescu
Jan 19, 2016·Annales de pathologie·Cécile HamardMarie Wislez
Feb 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·D Ross CamidgeRobert C Doebele
Dec 18, 2013·Seminars in Diagnostic Pathology·Giulio RossiRaffaele Califano
Oct 3, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Fumihiro YamaguchiKunihiko Fukuchi
Apr 9, 2014·Neoplasia : an International Journal for Oncology Research·Shirish ShuklaDipankar Ray
Jun 28, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yasushi YatabeCharles A Powell
Mar 23, 2011·Seminars in Oncology·Ravi SalgiaEverett E Vokes
Mar 10, 2011·Cancer·Seiichi KakegawaIzumi Takeyoshi
May 24, 2012·Diagnostic Cytopathology·Benjamin L WittSharon Hirschowitz
Apr 28, 2012·Journal of Experimental & Clinical Cancer Research : CR·Hong LiangKe Wang

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