PMID: 9537934Dec 16, 1998Paper

Biological and virologic characteristics of primary HIV infection

Annals of Internal Medicine
T W SchackerL Corey

Abstract

The clinical events surrounding acute HIV-1 infection have been well described, but little is known about whether the virologic course of acute HIV-1 infection influences the subsequent progression of disease. To define the virologic natural history of acute and very early HIV infection. Prospective, longitudinal cohort study. University of Washington Research Clinic 74 adults enrolled soon after acquisition of HIV (mean, 69 days). Plasma HIV-1 RNA levels; quantitative cell cultures; CD4 cell counts; and detailed clinical assessments done at study entry, biweekly for 1 month, monthly for 2 months, and quarterly thereafter. In the first 30 days after acquisition of HIV, HIV-1 RNA levels varied greatly among participants (range, 27,200 to 1.6 x 10(6) copies per mL of plasma). Levels of HIV-1 RNA decreased by a mean of 6.5% per week for the first 120 days and then increased by a mean of 0.15% per week. CD4 cell counts decreased by a mean of 5.2 cells/mm3 per week for the first 160 days and by a mean of 1.9 cells/mm3 per week thereafter (P < 0.01). Disease progressed faster in participants who sought medical care for their acute seroconversion syndrome (P = 0.01) and those who had high plasma HIV-1 RNA levels 120 to 365 days after ...Continue Reading

Citations

Jan 18, 2005·Clinical Evidence·Martin Talbot
Feb 21, 2002·Current Infectious Disease Reports·Joanne Stekler, Ann Collier
Oct 6, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Lena Al-HarthiAlan Landay
Jan 12, 1999·Disease-a-month : DM·H W HorowitzG P Wormser
Oct 4, 2005·Nature Reviews. Immunology·Ashley T Haase
Dec 17, 2009·Nature Reviews. Immunology·Andrew J McMichaelBarton F Haynes
Nov 26, 2010·The New England Journal of Medicine·Robert M GrantUNKNOWN iPrEx Study Team
Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L LavreysJ Kreiss
Jun 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ludo LavreysJoan K Kreiss
Dec 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan M PincusKenneth A Freedberg
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sigall Kassutto, Eric S Rosenberg
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elizabeth ConnickThomas B Campbell
Feb 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cécile GoujardUNKNOWN Agence Nationale de Recherche sur le Sida PRIMO Study Group
Apr 6, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ludo LavreysJulie Overbaugh
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pierre TattevinChristian Michelet
Mar 17, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alethea W McCormickGeorge R Seage
Jun 30, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jared M BaetenJulie Overbaugh
Oct 11, 2008·AIDS Research and Human Retroviruses·Joanne SteklerRobert W Coombs
Jun 7, 2003·Journal of Urban Health : Bulletin of the New York Academy of Medicine·J M RaboudM T Schechter
Jan 31, 2002·AIDS·J J Eron, P Vernazza
Mar 2, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hong-Ha M TruongLawrence Corey
Oct 4, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marijn van BallegooijenJaap Goudsmit
Jun 24, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kate BuchaczTimothy D Mastro
Jul 4, 2006·AIDS·Joanne SteklerAnn C Collier
May 4, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jared M BaetenAnn Duerr
Dec 20, 2007·AIDS·Kimberly A PowersUNKNOWN Malawi UNC Project Acute HIV Study Team

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.