Biological approaches to therapy of pancreatic cancer.

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Han Hsi Wong, Nicholas Lemoine

Abstract

Pancreatic cancer is a lethal disease and notoriously difficult to treat. Only a small proportion is curative by surgical resection, whilst standard chemotherapy for patients with advanced disease has only modest effect with substantial toxicity. Clearly there is a need for the continual development of novel therapeutic agents to improve the current situation. Improvement of our understanding of the disease has generated a large number of studies on biological approaches targeting the molecular abnormalities of pancreatic cancer, including gene therapy and signal transduction inhibition, antiangiogenic and matrix metalloproteinase inhibition, oncolytic viral therapy and immunotherapy. This article provides a review of these approaches, both investigated in the laboratories and in subsequent clinical trials.

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Citations

Jun 2, 2010·Cancer Immunology, Immunotherapy : CII·A HellerN A Giese
Apr 13, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yong ChenXiShan Hao
Oct 15, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sant P ChawlaFrederick L Hall
Nov 17, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Han Hsi WongYaohe Wang
Jul 14, 2010·Future Oncology·Han Hsi Wong, Nicholas R Lemoine
Oct 16, 2009·Expert Review of Anticancer Therapy·Malte Buchholz, Thomas M Gress
Apr 9, 2013·Science China. Life Sciences·Shanglong LiuYupei Zhao
Oct 14, 2014·World Journal of Gastroenterology : WJG·Si-Xue LiuYing-Qiang Zhong

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