PMID: 2499342Feb 1, 1989Paper

Biological availability of glycerol trinitrate after sublingual administration

Arzneimittel-Forschung
N RietbrockB Muck

Abstract

The relative bioavailability of a glyceryl trinitrate (GTN) spray (Nitro-Corangin Spray) compared to that of another GTN Spray was evaluated in 12 healthy male volunteers using an open, randomized cross-over design with two treatment phases. The parameters Cmax, tmax and AUC0-1 showed no statistically significant differences between the two treatments. It is concluded that the two GTN-Sprays may be considered bioequivalent.

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