Biological barriers, and the influence of protein binding on the passage of drugs across them.

Molecular Biology Reports
Karolina Wanat

Abstract

Drug-protein binding plays a key role in determining the pharmacokinetics of a drug. The distribution and protein binding ability of a drug changes over a lifetime, and are important considerations during pregnancy and lactation. Although proteins are a significant fraction in plasma composition, they also exist beyond the bloodstream and bind with drugs in the skin, tissues or organs. Protein binding influences the bioavailability and distribution of active compounds, and is a limiting factor in the passage of drugs across biological membranes and barriers: drugs are often unable to cross membranes mainly due to the high molecular mass of the drug-protein complex, thus resulting in the accumulation of the active compounds and a significant reduction of their pharmacological activity. This review describes the consequences of drug-protein binding on drug transport across physiological barriers, whose role is to allow the passage of essential substances-such as nutrients or oxygen, but not of xenobiotics. The placental barrier regulates passage of xenobiotics into a fetus and protects the unborn organism. The blood-brain barrier is the most important barrier in the entire organism and the skin separates the human body from the e...Continue Reading

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Citations

May 13, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Soghra Bagheri, Ali A Saboury
Sep 14, 2021·Journal of Biomolecular Structure & Dynamics·Toheeb Adewale BalogunDamilola Alex Omoboyowa
Sep 8, 2021·The Journal of Physical Chemistry. B·Natalia Rojas-ValenciaAlbeiro Restrepo

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

LactMed

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