Biological characteristics and medical treatment of breast cancer in young women-a featured population: results from the NORA study.

International Journal of Breast Cancer
P PronzatoM E Cazzaniga

Abstract

The present paper described the biological characteristics and clinical behavior of young women in the cohort NORA study From 2000-2002, patients (N > 3500) were enrolled at 77 Italian hospitals. Women aged ≤50 years (N = 1013) were stratified into age groups (≤35, 36-40, 41-45, and 46-50 years). The relationship between age and patient characteristics, cancer presentation, and treatment was analyzed. Younger women more frequently had tumors with ER/PgR-negative(χ(2) = 7.07; P = .008), HER2 amplification (χ(2) = 5.76; P = .01), and high (≥10%) Ki67 labelling index (χ(2) = 9.53; P = .002). Positive nodal status, large tumors, and elevated Ki67 all associated with the choice for chemotherapy followed by endocrine therapy in hormone receptor-positive patients (P < .0001). At univariate analysis, ER-ve status, chemotherapy and age resulted as the only statistically significant variables (HR = 2.02, P = .004, and >40 versus ≤40, P < .0001, resp.). At multivariate analysis, after adjustment for significant clinical and pathological factors, age remains a significant prognostic variable (HR = 0.93, P = .0021). CONCLUSION. This cohort study suggests that age per sè is an important prognostic factor. The restricted role of early diagnos...Continue Reading

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Citations

Oct 1, 2013·Human Reproduction Update·Vânia GonçalvesGwendolyn Quinn
Jun 12, 2013·Current Oncology Reports·Carlos G FerreiraAngélica Nogueira-Rodrigues
Apr 17, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Akemi KataokaMika Miyashita
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Aug 27, 2016·Human Fertility : Journal of the British Fertility Society·Vânia Gonçalves, Gwendolyn P Quinn
Apr 5, 2017·Journal of Genetic Counseling·Neha RajpalKristi D Graves
Aug 16, 2019·MMW Fortschritte der Medizin·D-Maximiliane BurgmannRachel Würstlein
May 1, 2021·Journal of Clinical Medicine·Kenny A Rodriguez-WallbergFrida E Lundberg

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