Biological characteristics of a novel giant cell tumor cell line derived from spine

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Zhenhua ZhouJianru Xiao

Abstract

Giant cell tumor of bone(GCTB) is a special bone tumor for it consists of various cell types, and its biological characteristics is different from common benign or malignant neoplasm. In the present study, we report the biological features of a primary Asian GCTB cell line named GCTB28. We analyzed extensive properties of the GCTB28 cells including morphological observations, growth, cell cycle, karyotype, proliferation, proteins expression, surface biomarker verification, and tumorigenicity in nude mice. We found that the stromal cells of GCTB were endowed with self-renewal capacity and played dominant roles in GCTB development. Moreover, we confirmed that GCTB cells can be CD33(-)CD14(-) phenotype which was not in accord with previous study. This study provides an in vitro model system to investigate pathogenic mechanisms and molecular characteristics of GCTB and also provides a useful tool for researching the therapeutic targeting of GCTB.

References

Feb 1, 1987·The Journal of Clinical Investigation·S R GoldringA K Bhan
Oct 3, 2006·International Orthopaedics·Mathias Werner
Aug 25, 2007·Journal of Pediatric Orthopedics·Ajay PuriSanica Behle
Jan 29, 2008·Current Pharmaceutical Design·Mahesh C Sharma, Meena Sharma
Sep 5, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ramses G ForsythPancras C W Hogendoorn
Jun 11, 2009·British Journal of Cancer·Y OhnoM Tachibana
Aug 13, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Kabul Chandra SaikiaFiroz Ahmed
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Haiyan ZhaiStella E Tsirka
May 23, 2012·The Journal of International Medical Research·C C ShenZ M Yang
Aug 25, 2012·Genomics, Proteomics & Bioinformatics·Shishan DengZhengwei Yang
Oct 16, 2012·Bone·Robert W Cowan, Gurmit Singh
Jan 17, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Corey J ChakarunGeorge R Matcuk
Feb 5, 2013·The Journal of the American Academy of Orthopaedic Surgeons·Kevin A RaskinFrancis J Hornicek
Mar 5, 2014·Disease Markers·Chi-Yun Wang, Chiou-Feng Lin
Jul 19, 2014·Clinical and Experimental Medicine·Mariana Ferreira LealMarília Cardoso Smith
Aug 26, 2014·Revista española de cirugía ortopédica y traumatología·F AbatI Grácia
Dec 3, 2014·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Rajiv RajaniC Parker Gibbs
Dec 19, 2014·Cancer Biomarkers : Section a of Disease Markers·Jie YangChaoqi Liu
Dec 19, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ya-Kai HuangShan Zhu
Jan 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong LiuHan Liang
Mar 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hafeza AkterMin-Jung Kang
Mar 6, 2015·The Journal of Bone and Joint Surgery. American Volume·Chung Ming ChanC Parker Gibbs
Mar 12, 2015·Oncology Reports·Xiao-Heng XuYan-Qiu Song
Apr 4, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chang Dong YeoJin Woo Kim

❮ Previous
Next ❯

Citations

Feb 22, 2018·Cell Death & Disease·Zhenhua ZhouJianru Xiao
Jul 15, 2021·Pathology Oncology Research : POR·Kemal Behzatoglu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
Hong-tao LiRi-quan Lai
© 2022 Meta ULC. All rights reserved