Biological characteristics of growth hormone-producing pituitary adenomas are different according to responsiveness to thyrotropin-releasing hormone

The Journal of Clinical Endocrinology and Metabolism
Hideyuki AritaYouichi Saitoh

Abstract

The paradoxical response of GH to TRH in patients with acromegaly has been previously reported. However, few reports have focused on tumor characteristics reflected by this response. This study aimed to clarify the relationship between TRH-induced GH responsiveness and other tumor characteristics. Patients with acromegaly who underwent initial surgery between 2000 and 2012 were divided into TRH-responder and nonresponder groups. Clinical features were compared between the two groups with respect to tumor size, Knosp grade, endocrinological profiles, and histopathological findings revealed by cytokeratin staining. Tumor size was quantitatively evaluated with volumetry. Cytokeratin staining patterns were categorized into three groups: sparsely granulated type, densely granulated type, and intermediate type. Sixty-two patients were included in the study. TRH responders (n = 45) showed significantly smaller tumor size than nonresponders (n = 17) (2.78 ± 4.71 vs. 7.56 ± 9.00 ml, P < 0.005). In addition, TRH responders showed significantly higher preoperative basal GH per volume ratio than nonresponders (10.1 ± 8.4 vs. 7.72 ± 11.85 ng/ml(2), P < 0.05). Logarithmic regression modeling showed significant correlation between TRH respons...Continue Reading

Citations

May 16, 2013·Reproductive Biology and Endocrinology : RB&E·Juan J TarínAntonio Cano
Dec 19, 2013·International Journal of Endocrinology·Sang Ouk ChinSung-Woon Kim
Oct 12, 2013·Clinical Endocrinology·Yuko GotoYouichi Saitoh
Nov 19, 2014·Cell Biochemistry and Biophysics·Jing-Min ChengYan-chao Zhang
Oct 5, 2018·The Journal of Clinical Endocrinology and Metabolism·Carla ScaroniGianluca Occhi
Nov 27, 2018·The Journal of Clinical Endocrinology and Metabolism·Kosuke MukaiIichiro Shimomura

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