Biological coating for arterial stents: the next evolutionary change in stents

Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists
Kevin CarnevaleTimur P Sarac

Abstract

To describe the in vivo results of a promising new stent-graft lined with peritoneum. Eighteen dogs underwent balloon angioplasty injury to the bilateral iliac arteries followed by placement of either an 8-mm x 5-cm glutaraldehyde-fixed bovine peritoneum- lined balloon-expandable stent (PLS) or a similarly sized, commercially prepared, polyester-lined self-expanding stent (DLS) as a control. Animals were sacrificed at 1 and 6 months. Biplanar arteriography and intravascular ultrasound were done at the time of sacrifice, and the vessels were harvested after perfusion fixation for histology/morphometry. Immunofluorescence with CD34 and factor VIII staining was used to evaluate endothelialization, while alpha-actin was used to quantify smooth muscle cell (SMC) deposition. At 1 month, all vessels were patent in both groups. At 6 months, 8 of 9 vessels were open in the PLS group versus 6 of 9 in the control DLS group. Vessel lumen diameter at 1 month was significantly greater in the PLS vessels compared to the DLS group at 1 cm above the stent (35.9 +/- 4.4 versus 29.4 +/- 4.7 mm2; p = 0.02) and 1 cm below the stent (37.2 +/- 7.1 versus 25.2 +/- 3.2 mm2; p = 0.005); these results persisted to 6 months. Histological morphometry demon...Continue Reading

References

Nov 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J FingerleM A Reidy
Jul 1, 1995·Journal of Vascular Surgery·T P SaracR M Green
May 1, 1996·Journal of Vascular and Interventional Radiology : JVIR·M HenryN Touchot
Feb 1, 1997·Catheterization and Cardiovascular Diagnosis·C StefanadisP Toutouzas
Sep 5, 2001·Journal of Vascular Surgery·P R NelsonJ L Cronenwett
Aug 10, 2002·Journal of Vascular Surgery·Giorgio M BiasiStefano A Ferrari
Mar 13, 2003·Journal of Vascular and Interventional Radiology : JVIR·Stephan H DudaKarl K Haase
Mar 13, 2003·Journal of Vascular and Interventional Radiology : JVIR·David C MadoffBarry D Toombs
May 24, 2003·Journal of Vascular Surgery·Eva M RzucidloJack L Cronenwett
Aug 23, 2003·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Peter J BrayAlan E Bray
Dec 19, 2003·Journal of Vascular Surgery·Todd R VogelAlan M Graham
Dec 24, 2004·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Thomas ZellerFranz-Josef Neumann
Feb 3, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brian S RifkinMark A Perazella
Mar 11, 2005·Journal of Vascular and Interventional Radiology : JVIR·Stephan H DudaJean P Bérégi
Mar 12, 2005·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Giancarlo Biamino
Apr 20, 2005·Journal of Vascular Surgery·Timur P SaracKenneth Ouriel

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Citations

Oct 8, 2014·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Jennifer M BastijanicTimur P Sarac

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