Biological diagnosis for neuroblastoma using the combination of highly sensitive analysis of prognostic factors

Journal of Pediatric Surgery
Tatsuro TajiriS Suita

Abstract

To select the optimal treatment according to the degree of malignancy of neuroblastoma, it is essential to accurately and rapidly identify any genetic abnormalities associated with the prognosis. This study aims to assess the correlation between the combination of prognostic factors and the biologic findings of neuroblastoma using a highly sensitive analysis of prognostic factors. In 44 neuroblastoma primary samples, we determined the gene dosages of MYCN and Survivin (as the target of 17q gain) and the expression levels of MYCN, Survivin, and BIN1 using highly sensitive analysis (the quantitative polymerase chain reaction method); furthermore, we assessed the correlation between the combination of their prognostic factors and the biology of neuroblastoma. The gene dosage of MYCN or Survivin was significantly associated with all known prognostic factors. The expression level of MYCN or Survivin was not significantly associated with any prognostic factors, whereas the expression level of BIN1 was significantly associated with 5 of 6 prognostic factors. Regarding the combination of MYCN amplification and 17q gain (the gene dosage of Survivin), and the low expression of BIN1, the rates of advanced stages (stage III or IV) were 100...Continue Reading

References

Feb 14, 1991·The New England Journal of Medicine·W M Crist, L E Kun
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G M Brodeur
Mar 1, 1997·Journal of Pediatric Hematology/oncology·G M BrodeurP S White
Aug 1, 1997·Journal of Pediatric Surgery·T KusafukaA Okada
Dec 23, 2004·Seminars in Cancer Biology·Luis A Diaz

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Citations

Dec 18, 2007·Journal of Pediatric Surgery·Tatsuro TajiriTomoaki Taguchi
May 7, 2009·Pediatric Blood & Cancer·Xiaoling ZhongLinda H Malkas
Nov 14, 2008·Pediatric Blood & Cancer·Marta PiquerasRosa Noguera
Mar 4, 2011·Pediatric Blood & Cancer·Valérie CombaretAlain Puisieux
Aug 7, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lisa SimiClaudio Orlando

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