Biological dose estimation for charged-particle therapy using an improved PHITS code coupled with a microdosimetric kinetic model

Radiation Research
Tatsuhiko SatoLembit Sihver

Abstract

Microdosimetric quantities such as lineal energy, y, are better indexes for expressing the RBE of HZE particles in comparison to LET. However, the use of microdosimetric quantities in computational dosimetry is severely limited because of the difficulty in calculating their probability densities in macroscopic matter. We therefore improved the particle transport simulation code PHITS, providing it with the capability of estimating the microdosimetric probability densities in a macroscopic framework by incorporating a mathematical function that can instantaneously calculate the probability densities around the trajectory of HZE particles with a precision equivalent to that of a microscopic track-structure simulation. A new method for estimating biological dose, the product of physical dose and RBE, from charged-particle therapy was established using the improved PHITS coupled with a microdosimetric kinetic model. The accuracy of the biological dose estimated by this method was tested by comparing the calculated physical doses and RBE values with the corresponding data measured in a slab phantom irradiated with several kinds of HZE particles. The simulation technique established in this study will help to optimize the treatment p...Continue Reading

References

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Citations

Apr 1, 2010·Annals of the ICRP·N Petoussi-HenssUNKNOWN International Commission on Radiation Units and Measurements
Aug 10, 2011·International Journal of Radiation Biology·Tatsuhiko SatoKoji Niita
Mar 23, 2012·International Journal of Radiation Oncology, Biology, Physics·Nicholas B RemmesJon J Kruse
Sep 23, 2016·Scientific Reports·G BaioccoA Ottolenghi
Oct 30, 2010·Physics in Medicine and Biology·Taku InaniwaKoji Noda
Dec 17, 2010·Journal of Radiation Research·Yuki KaseNaruhiro Matsufuji
Jun 10, 2015·Physics in Medicine and Biology·Monika Puchalska, Lembit Sihver
Jan 1, 2016·International Journal of Particle Therapy·George Dedes, Katia Parodi
Dec 4, 2020·Journal of Applied Clinical Medical Physics·Hisashi NakanoHiroyuki Ishikawa
Feb 16, 2021·Physics in Medicine and Biology·Yusuke MatsuyaHooshang Nikjoo
Jul 2, 2021·Radiological Physics and Technology·Takuya Furuta, Tatsuhiko Sato
Jul 21, 2021·Life Sciences in Space Research·Walter TinganelliMarco Durante

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Methods Mentioned

BETA
X-ray
irradiating

Software Mentioned

HIBRAC
TRACEL
PHITS
PARTRAC
PHITS Transport code
HIMAC
PITS
JQMD

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