Abstract
Cardiac magnetic resonance (CMR) is increasingly used for the diagnosis and management of cardiac diseases. Recent studies have reported immediate post-CMR DNA double-strand breaks in T lymphocytes. We sought to evaluate CMR-induced DNA damage in lymphocytes, alterations of blood cells, and their temporal persistence. In 20 prospectively enrolled healthy men (31.4±7.9 years), blood was drawn before and after (1-2 hours, 2 days, 1 month, and 1 year) unenhanced 1.5T CMR. Blood cell counts, cell death, and activation status of lymphocytes, monocytes, neutrophils, and platelets were evaluated. The first 2-hour post-CMR were characterized by a small increase of lymphocyte B and neutrophil counts and a transient drop of total lymphocytes because of a decrease in natural killer cells. Among blood cells, only neutrophils and monocytes displayed slight and transient activation. DNA double-strand breaks in lymphocytes were quantified through flow cytometric analysis of H2AX phosphorylation (γ-H2AX). γ-H2AX intensity in T lymphocytes did not change early after CMR but increased significantly at day 2 ≤1 month before returning to baseline levels of 1-year post-CMR. Unenhanced CMR is associated with minor but significant immediate blood cel...Continue Reading
References
Jan 1, 1996·The Biochemical Journal·H Wiseman, B Halliwell
May 20, 1998·Journal of Toxicology and Environmental Health. Part a·D FlipoK Krzystyniak
Mar 10, 2001·Nature Genetics·K K Khanna, S P Jackson
Nov 21, 2002·Cytometry·Laura TeodoriZbigniew Darzynkiewicz
Apr 26, 2003·Mechanisms of Ageing and Development·Salvatore ScarpaciGino Doria
Jul 9, 2003·Immunological Reviews·Kevin D MillsFrederick W Alt
Apr 9, 2004·Lancet·Amy Berrington de González, Sarah Darby
Nov 24, 2004·Progress in Biophysics and Molecular Biology·Junji Miyakoshi
Jun 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Markus LöbrichMichael Uder
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mahmut OzsahinDavid Azria
Sep 16, 2006·Carcinogenesis·Stefano BonassiMichael Fenech
Oct 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Nina F SchwenzerEnno Rodegerdts
Jul 5, 2008·Nature Protocols·Aida MuslimovicOla Hammarsten
Sep 23, 2008·Mutation Research·Silvana SimiMassimo Lombardi
Dec 24, 2008·Nature Reviews. Immunology·Kenneth DorshkindRobert A J Signer
Mar 7, 2009·Pathophysiology : the Official Journal of the International Society for Pathophysiology·J L PhillipsH Lai
May 19, 2009·Investigative Radiology·Michael A KuefnerMichael Uder
Mar 18, 2011·Bioelectromagnetics·Joong Won LeeHai Won Chung
Jan 17, 2013·Electromagnetic Biology and Medicine·Mohammad Reza AhmadianpourSaman Hosseinkhani
Jan 29, 2013·PloS One·Shanshan XuZhengping Xu
Feb 6, 2013·Frontiers in Immunology·Loems Ziegler-Heitbrock, Thomas P J Hofer
Jun 25, 2013·European Heart Journal·Michael FiechterPhilipp A Kaufmann
Jul 4, 2013·European Heart Journal·Juhani KnuutiHeikki Minn
Jul 13, 2013·JACC. Cardiovascular Imaging·Eike Nagel, Jagat Narula
Sep 13, 2013·BioMed Research International·Soumaya GhodbaneHafedh Abdelmelek
Feb 1, 2014·Drug and Chemical Toxicology·Seunghyun ChoHai Won Chung
May 24, 2014·European Heart Journal Cardiovascular Imaging·Steffen E PetersenUNKNOWN Education Committee of European Association of Cardiovascular Imaging Association (EACVI)
May 7, 2015·European Heart Journal Cardiovascular Imaging·Patrizio LancellottiGilbert Habib
Citations
Jan 21, 2016·Radiology·Philipp A Kaufmann
Mar 21, 2016·NeuroImage·Mahsa FatahiOliver Speck
May 7, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Prem Soman, Andrew J Einstein
Jun 9, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sabha BhattiAndrew J Einstein
Aug 24, 2016·European Heart Journal Cardiovascular Imaging·M A HillW G McKenna
Jul 19, 2016·Current Opinion in Pediatrics·Puja Banka, Tal Geva
Oct 1, 2016·Radiology·Annika ReddigBjörn Friebe
May 26, 2017·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Exequiel ReynosoPatricia Carrascosa
Jan 26, 2017·Health Physics·UNKNOWN International Commission on Non-Ionizing Radiation Protection (ICNIRP)
Jan 6, 2017·Radiation Research·Kenneth R FosterThomas F Budinger
Jan 25, 2017·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Hussein Jaffer, Kieran J Murphy
Nov 23, 2017·European Heart Journal·William R CritchleyChristopher A Miller
May 2, 2018·Radiology·Saravanabavaan SuntharalingamKai Nassenstein
Sep 1, 2017·AJR. American Journal of Roentgenology·Gaston A Rodriguez-GranilloPatricia Carrascosa
Sep 5, 2015·Circulation. Cardiovascular Imaging·Philipp A Kaufmann
Feb 15, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Christopher L Hansen, Rittu Hingorani
Oct 24, 2017·European Heart Journal·Alessia GimelliUNKNOWN EACVI Scientific Documents Committee
Nov 30, 2018·European Radiology Experimental·Björn FriebeAnnika Reddig
Mar 12, 2020·Bioelectromagnetics·Jonna WilénKjell Hansson Mild
Mar 28, 2019·Radiation Protection Dosimetry·Volodymyr Vinnikov, Oleg Belyakov
Oct 8, 2017·European Radiology·Martin FasshauerJoachim Lotz
Dec 28, 2017·European Heart Journal·Mark A Hill
Jan 9, 2018·PloS One·Jennifer S McDonaldDavid F Kallmes
Apr 30, 2020·EJNMMI Research·Gunnar BrixMatthias Eiber
May 24, 2020·European Journal of Radiology·Amir Hossein JalaliHossein Ghanaati
Sep 30, 2021·Medical & Biological Engineering & Computing·Valentina HartwigGiulio Giovannetti