Biological Effects of Low-Dose Chest CT on Chromosomal DNA

Radiology
Hiroaki SakaneSatoshi Tashiro

Abstract

Background Although the National Lung Screening Trial reported a significant reduction in lung cancer mortality when low-dose (LD) CT chest examinations are used for a diagnosis, their biologic effects from radiation exposure remain unclear. Purpose To compare LD CT and standard-dose (SD) CT for DNA double-strand breaks and chromosome aberrations (CAs) in peripheral blood lymphocytes. Materials and Methods Between March 2016 and June 2018, 209 participants who were referred to a respiratory surgery department for chest CT studies were prospectively enrolled in this study. Individuals were excluded if they had undergone radiography examinations within the last 3 days or had undergone chemotherapy or radiation therapy. Peripheral blood samples were obtained before and 15 minutes after CT. The number of γ-H2AX foci and unstable CAs in lymphocytes was quantified by immunofluorescent staining of γ-H2AX and by fluorescence in situ hybridization by using peptide nucleic acid probes for centromeres and telomeres, respectively. The Wilcoxon signed rank test was used for statistical analysis. Bonferroni correction was applied for multiple comparisons. Results Of the 209 participants (105 women, 104 men; mean age, 67.0 years ± 11.3 [stand...Continue Reading

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Citations

Aug 14, 2020·Emergency Radiology·Seyed Mohammad Hossein TabatabaeiHamid Rajebi
Feb 5, 2021·European Journal of Nuclear Medicine and Molecular Imaging·S SchumannH Scherthan
Sep 16, 2020·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Shangamithra VisweswaranVenkatachalam Perumal
May 29, 2021·European Radiology Experimental·Victor GombolevskiyJenia Vassileva

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