Biological effects of lysophosphatidic acid in the nervous system

International Review of Cell and Molecular Biology
Frisca FriscaAlice Pébay

Abstract

Lysophosphatidic acid (LPA) is a bioactive lipid that regulates a broad range of cellular effects in various cell types, leading to a variety of responses in tissues, including in the nervous system. LPA and its receptors are found in the nervous system, with different cellular and temporal profiles. Through its ability to target most cells of the nervous system and its induction of pleiotropic effects, LPA mediates events during neural development and adulthood. In this review, we summarize the current knowledge on the effects of LPA in the nervous system, during development and adulthood, and in various pathologies of the nervous system. We also explore potential LPA intervention strategies for anti-LPA therapeutics.

Citations

Mar 26, 2016·Journal of Neuroinflammation·Avinash ParimisettyChristian Lefebvre d'Hellencourt
Jun 24, 2018·International Journal of Molecular Sciences·Sindhu RameshMuralikrishnan Dhanasekaran
Dec 24, 2019·Frontiers in Cellular Neuroscience·Luke R JohnsonBoris Martinac
Jan 8, 2021·Frontiers in Neuroscience·Joseph R LoverdeBryan J Pfister
Jun 3, 2021·International Journal of Molecular Sciences·Bo YuBernard A J Roelen
Oct 7, 2021·PLoS Pathogens·Sushil KhatiwadaDaniel L Rock

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