PMID: 3757977Oct 1, 1986Paper

Biological effects of the respirable dusts from ore mines

Environmental Research
Z AdamisG Ungváry

Abstract

The biological effects of ore dusts were examined on peritoneal macrophages in vitro and on rat lung in vivo. The methylene blue adsorption of the dust samples, cytotoxicity, and phospholipid and hydroxyproline content of the lung were determined. It was realized that the examined ore samples had cytotoxic effects and from the in vitro results one can get information about the type of damage to be expected in the lung tissue. It is supposed that the examined ore dusts are less dangerous and slower acting than quartz, but they cause progressive fibrosis. The in vivo biochemical experiments do not give information about the type of damage to be expected in lung tissue; and the data on ore, bentonite, and coal do not differ from each other. To determine the typical biochemical changes caused by quartz, we obtain the most valuable information by determination of lung weight and phospholipid, phosphatidylcholine, and hydroxyproline content.

References

Sep 6, 1976·International Archives of Occupational and Environmental Health·Z Adamis, M Timár
Feb 1, 1964·The Biochemical Journal·V P SkipskiM Barclay
Jan 1, 1971·Internationales Archiv Für Arbeitsmedizin·J L KawS H Zaidi
Jan 1, 1973·British Journal of Industrial Medicine·M GrünspanW Dehnen
Mar 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·U Brockmann, G Gercken
Apr 1, 1959·The Journal of Pathology and Bacteriology·J MARKS, D M JAMES
Dec 1, 1964·Journal of Chromatography·T BICAN FISTER, V KAJGANOVIC
Jan 1, 1960·British Journal of Industrial Medicine·G S MARKS, L W MARASAS
Jan 1, 1932·The Biochemical Journal·E J King

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Citations

Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Nov 5, 2016·Inhalation Toxicology·L Daniel MaximErnest E McConnell
Dec 20, 2015·International Journal of Toxicology·Lillian C BeckerF Alan Andersen

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