Biological efficacy of low against medium dose aspirin regimen after coronary surgery: analysis of platelet function

Thrombosis and Haemostasis
Jacqueline CornelissenAlain Vuylsteke

Abstract

The failure of aspirin to inhibit platelet function has been documented in patients undergoing coronary artery bypass graft (CABG) surgery, but the causes of "aspirin-resistance" remain uncertain. The aim of this study was to investigate the efficacy of aspirin in patients undergoing CABG surgery receiving either 100 mg or 325 mg of oral aspirin for 5-days. Platelet function was tested the day before surgery and on day +1 and day +5, and evaluated by changes in collagen-induced thromboxane-A2 (TxA2) release and platelet aggregation following stimulation with collagen, ADP and epinephrine. In all patients, baseline platelet aggregation was significantly inhibited by pre-incubation with in vitro aspirin (150 micromol/l), with a mean reduction in TxA2-release of >or=95.5% (82.3,99.1). After 5-days of oral aspirin, platelet aggregation was significantly inhibited, and was not further inhibited by in vitro aspirin. Oral aspirin was also associated with a >or=99.5% (97.8, 99.7) reduction in TxA2-release, and with the reversal of the second-phase of ADP-induced aggregation which is TxA2-dependent. In addition a single-dose of 325 mg aspirin on the first post-operative morning may have a greater inhibitory effect on collagen-induced ag...Continue Reading

Citations

Aug 1, 2007·Journal of Thrombosis and Haemostasis : JTH·M Cattaneo
Feb 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P RousseauP Abraham
Jan 8, 2011·Anesthesia and Analgesia·Richard Hall, C David Mazer
Oct 16, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·O MeenG Erikssen
May 2, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Norbert ZimmermannThomas Hohlfeld
Nov 27, 2008·Journal of Cardiovascular Pharmacology·Gabriella PuschLaszlo Szapary

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