Abstract
We evaluated the relationship between biological behavior and microsatellite instability (MSI) status, with or without p53 status, in sporadic colorectal carcinoma. MSI was analyzed with regard to biological features such as cellular proliferation and apoptotic cell death, in addition to clinicopathological features, in 87 patients with sporadic colorectal carcinoma. Fourteen (16.1%) of 87 tumors showed instability at two or more of the five loci examined (high-frequency MSI [MSI-H]). Four demonstrated instability at one locus (low-frequency MSI [MSI-L]), and 69 showed no instability (microsatellite-stable [MSS]). The MSI-H tumors tended to be located in the proximal colon and more often were mucinous carcinoma. The MSI-H tumors also tended to be in patients with multiple colorectal carcinomas and to demonstrate, rarely, an infiltrating growth pattern or venous invasion. The incidence of p53 protein overexpression in the MSI-H tumors was significantly lower than that in the MSI-L/MSS tumors (21% vs 54%). There was no significant difference in the proliferating-cell nuclear antigen (PCNA) labeling index (PI) or apoptotic index (AI) between the MSI-H and MSI-L/MSS tumors. The AI in the MSI-H tumors with p53 overexpression was sig...Continue Reading
Citations
Apr 12, 2011·Cancer Chemotherapy and Pharmacology·Cristina P R XavierCristina Pereira-Wilson
Jan 15, 2008·International Journal of Colorectal Disease·Guoxiang CaiSanjun Cai
Oct 6, 2006·International Journal of Colorectal Disease·Cinzia AzzoniLeopoldo Sarli
Jul 31, 2012·The Journal of Nutritional Biochemistry·Cristina P R XavierCristina Pereira-Wilson
Aug 2, 2008·Surgical Oncology·Kjetil SøreideHartwig Kørner
Dec 7, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C HassanS Morini
Apr 4, 2012·PloS One·Guohong YuanWei Fu
Jul 20, 2016·Journal of Oncology·Ehsan Nazemalhosseini MojaradMohammad Reza Zali
Nov 12, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L GhanipourH Birgisson
Mar 24, 2006·The British Journal of Surgery·K SöreideJ P A Baak
Aug 12, 2014·World Journal of Gastroenterology : WJG·Mariusz Panczyk
Jan 11, 2005·The Journal of Pathology·D B Longley, P G Johnston
Jan 1, 2015·The Journal of Pathology. Clinical Research·Niek HugenIris D Nagtegaal
Oct 27, 2007·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kjetil Søreide