Biological fibrin used in anal fistulas: 31 patients

Annales de chirurgie
F JurczakJ-P Pousset

Abstract

The different treatments proposed for transsphincteric and suprasphincteric cryptoglandular anal fistulas are often complex and often associated with complications. After one or two stage anal fistulotomy, the risk of change in fecal continence ranks from 30% to 40%. This rate is lower (10%) with transanal advancement flap repair technique. A new therapeutic approach (fistula track closure by means of a fibrin sealant) that we have developed in our study allows to avoid classical sphincter dissection or section which could jeopardize normal sphincter function. Over a 20 month period, 31 consecutive patients (mean age: 42; 24 males and seven females) with transsphincteric (n = 28) or suprasphincteric (n = 3) anal fistula have been included in this study and treated with injection of a fibrin sealant into fistula track. Patients were controlled during a mean follow-up of 9 month. Fistula cure was obtained in 83.9% cases (75% after single fibrin sealant application). Success was achieved after a second application in two patients. Neither change in fecal continence nor other complication was observed during application and during follow-up period. This technique is simple (100% feasibility) and is reproductible. Results are compar...Continue Reading

References

Jan 1, 1991·Diseases of the Colon and Rectum·W R Schouten, T J van Vroonhoven
Jul 1, 1986·Diseases of the Colon and Rectum·A ChristensenJ Christiansen
Feb 1, 1984·Diseases of the Colon and Rectum·H C Kuypers
Jul 1, 1995·The British Journal of Surgery·W F Van Tets, J H Kuijpers
May 1, 1993·Diseases of the Colon and Rectum·M E AbelP A Volpe
Jun 1, 1993·Diseases of the Colon and Rectum·R K PearlH Abcarian
Jan 4, 1998·Diseases of the Colon and Rectum·Y H HoF Seow-Choen
Mar 21, 1998·The British Journal of Surgery·M E KreisM J Starlinger
Sep 25, 1999·Diseases of the Colon and Rectum·K S Venkatesh, P Ramanujam
Nov 24, 1999·Diseases of the Colon and Rectum·W R SchoutenJ W Briel
Jul 26, 2000·Diseases of the Colon and Rectum·J R CintronH Abcarian

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Citations

Sep 19, 2009·Journal de chirurgie·F JurczakJ-P Pousset
Mar 19, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Christos KontovounisiosSteven Wexner
Oct 17, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·D F AltomareF La Torre
May 14, 2010·The Cochrane Database of Systematic Reviews·Tarun J JacobMichael R B Keighley
Nov 25, 2011·Deutsches Ärzteblatt International·Andreas OmmerUNKNOWN German Society for General and Visceral Surgery

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