Biological Function of PD-L2 and Correlation With Overall Survival in Type II Endometrial Cancer

Frontiers in Oncology
Oliviero MarinelliMassimo Nabissi

Abstract

In cancer, upregulation of coinhibitory B7 ligands has been associated with immune evasion. So far, anti-programmed death-1 (PD-1) and anti-PD-ligand 1 (PD-L1) antibodies have been used in immuno-oncology, with promising outcomes; however, it is still needed to identify other markers, especially for endometrial cancer (EC). EC is a gynecological malignancy historically classified into two types: type I, with mostly estrogen-dependent endometrioid diseases, and the most aggressive type II, including mainly estrogen-independent and non-endometrioid tumors. PD ligand-2 (PD-L2) is known as the second ligand of the PD-1 receptor and, upon its binding, contributes to T-cell exhaustion. Up to now, very few information are available about PD-L2 in cancers, and no data have been reported for EC. The aim of this work was to characterize the PD-L1 and PD-L2 ligand expression profile in EC cell lines, focusing the attention on the biological role of PD-L2 and its prognostic impact in human type II EC biopsies. Using in silico analysis of TCGA data, we performed a molecular profiling in a cohort of 506 patients, both types I and II, and PD-1 ligands expression was also analyzed in different primary human EC cell lines. Moreover, PD-L2 stain...Continue Reading

References

Nov 28, 2006·Biochimica Et Biophysica Acta·James A McCubreyRichard A Franklin
Jan 29, 2008·Blood·Takeshi AzumaLieping Chen
May 3, 2011·Trends in Biochemical Sciences·Michelle C MendozaJohn Blenis
May 23, 2012·Clinical & Developmental Immunology·Esdy N RozaliW Joost Lesterhuis
May 3, 2013·Nature·Cyriac KandothDouglas A Levine
Nov 19, 2013·Archives of Pathology & Laboratory Medicine·Patrick L FitzgibbonsSharon Nofech-Mozes
Mar 25, 2014·Cancer Immunology, Immunotherapy : CII·Anke VanderstraetenFrederic Amant
Oct 17, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Antonio CallesPasi A Jänne
Dec 8, 2015·Experimental and Therapeutic Medicine·Jia LiuYanhong Che
Dec 19, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J ChenX D Zhang
Feb 3, 2016·Oncology Letters·Kenzo Sonoda
Dec 27, 2016·Frontiers in Immunology·Kankana BardhanVassiliki A Boussiotis
Aug 12, 2017·Cancer Treatment Reviews·Jole VentrigliaChiara Della Pepa
Oct 23, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Qiu-Xia QuXue-Guang Zhang
Dec 23, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Ede BirtalanLaszlo Tamas
Aug 15, 2018·International Journal of Molecular Sciences·Michiel Remmerie, Veerle Janssens
Aug 23, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Nuran SunguFazli Erdoğan
Oct 3, 2018·Signal Transduction and Targeted Therapy·David EscorsGrazyna Kochan
Oct 12, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Frédéric AmantCarien L Creutzberg
Mar 20, 2019·Journal of Gynecologic Oncology·Chiara Di TucciPierluigi Benedetti Panici
Apr 4, 2019·Molecular Medicine Reports·Xiang ShiXianrong Zhou
Nov 5, 2019·Frontiers in Oncology·Oliviero MarinelliMassimo Nabissi

❮ Previous
Next ❯

Citations

Jul 3, 2021·Biomedicines·Sandrine Rousset-RouviereRenaud Sabatier

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA Seq
PCR
Scanning Microscopy
transfection
transfections
Assay
ELISA
Biopsies

Software Mentioned

XLSTAT
Zeiss Zen
NIS Element Imaging
NIH Image J
Prism
GraphPad
ZEN
cBioPortal
Quantity One
Graph Pad

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Related Papers

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Nuran SunguFazli Erdoğan
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Jennifer H YearleyTerrill McClanahan
© 2021 Meta ULC. All rights reserved