Biological functions of mouse seminal vesicle fluid. II. Role of water-soluble fraction of seminal vesicle fluid as a nonspecific immunomodulator

Archives of Andrology
M EmotoS Kashiba

Abstract

The suppressive mechanisms of T cells induced by water-soluble fraction of mouse seminal vesicle fluid (WSF-SVF) were investigated to clarify its immunological roles in the reproductive immunity. WSF-SVF inhibited the blastogenic responses to concanavalin A (Con A) or phytohemagglutinin (PHA) of T cells. Pretreatment of splenocytes with WSF-SVF did not suppress the blastogenesis of splenocytes to Con A when treated cells were washed before cultures. WSF-SVF did not inhibit the proliferation of Con A-activated splenocytes, that of listeria-immune splenocytes to listeral antigen and growth of tumor cells (Yac 1 cells, Ehrlich ascites carcinoma cells, EL 4 cells). Listerial antigen-specific immune response was not observed when mice were immunized with both listerial antigen and WSF-SVF, whereas it was observed when mice were immunized with only listerial antigen. WSF-SVF also significantly inhibited allogenic MLR. WSF-SVF did not adsorb Con A, and its suppressive activity was rather enhanced by heating at 56 degrees C for 30 min. These results suggest that WSF-SVF inhibits the stage of sensitization of T cells with antigen or stimulant, such as mitogen nonspecifically, without adsorption to antigen or mitogen, and its substance i...Continue Reading

References

Feb 27, 1975·Nature·D P Stites, R P Erickson
Jan 1, 1976·Scandinavian Journal of Immunology·C PrakashG Möller
Feb 1, 1987·Fertility and Sterility·N J Alexander, D J Anderson
Oct 1, 1989·American Journal of Reproductive Immunology : AJRI·M EmotoS Kashiba
Jan 1, 1985·Archives of Andrology·R StanĕkE Sedláková
Aug 1, 1987·American Journal of Reproductive Immunology and Microbiology : AJRIM·J P BouvetJ Pillot
Aug 1, 1985·Journal of Reproductive Immunology·K James, S Szymaniec
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jul 1, 1984·American Journal of Reproductive Immunology : AJRI·T H Tarter, N J Alexander
Dec 1, 1984·Immunology Today·K James, T B Hargreave

❮ Previous
Next ❯

Citations

Aug 1, 1991·International Journal of Andrology·M EmotoS Kashiba

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.