Abstract
The suppressive mechanisms of T cells induced by water-soluble fraction of mouse seminal vesicle fluid (WSF-SVF) were investigated to clarify its immunological roles in the reproductive immunity. WSF-SVF inhibited the blastogenic responses to concanavalin A (Con A) or phytohemagglutinin (PHA) of T cells. Pretreatment of splenocytes with WSF-SVF did not suppress the blastogenesis of splenocytes to Con A when treated cells were washed before cultures. WSF-SVF did not inhibit the proliferation of Con A-activated splenocytes, that of listeria-immune splenocytes to listeral antigen and growth of tumor cells (Yac 1 cells, Ehrlich ascites carcinoma cells, EL 4 cells). Listerial antigen-specific immune response was not observed when mice were immunized with both listerial antigen and WSF-SVF, whereas it was observed when mice were immunized with only listerial antigen. WSF-SVF also significantly inhibited allogenic MLR. WSF-SVF did not adsorb Con A, and its suppressive activity was rather enhanced by heating at 56 degrees C for 30 min. These results suggest that WSF-SVF inhibits the stage of sensitization of T cells with antigen or stimulant, such as mitogen nonspecifically, without adsorption to antigen or mitogen, and its substance i...Continue Reading
References
Feb 27, 1975·Nature·D P Stites, R P Erickson
Jan 1, 1976·Scandinavian Journal of Immunology·C PrakashG Möller
Mar 1, 1978·Clinical Immunology and Immunopathology·Z H MarcusE V Hess
Jan 1, 1990·Archives of Andrology·M EmotoS Kashiba
Feb 1, 1987·Fertility and Sterility·N J Alexander, D J Anderson
Jan 1, 1989·Biochemical Pharmacology·S MetaforaR Porta
Oct 1, 1989·American Journal of Reproductive Immunology : AJRI·M EmotoS Kashiba
Jan 1, 1985·Archives of Andrology·R StanĕkE Sedláková
Aug 1, 1987·American Journal of Reproductive Immunology and Microbiology : AJRIM·J P BouvetJ Pillot
Jan 1, 1985·Immunology Letters·Z H MarcusL M Lewin
Aug 1, 1985·Journal of Reproductive Immunology·K James, S Szymaniec
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jan 1, 1983·AIDS Research·K JamesR T Cullen
Jan 1, 1982·Advances in Immunology·T A Waldmann, S Broder
Jul 1, 1984·American Journal of Reproductive Immunology : AJRI·T H Tarter, N J Alexander
Dec 1, 1984·Immunology Today·K James, T B Hargreave