Biological implications of circulating soluble intercellular adhesion molecule-1 in colorectal cancer patients

Scandinavian Journal of Gastroenterology
T ArakiMasato Kusunoki

Abstract

Intercellular adhesion molecule-1 (ICAM-1) is assumed to play a role in cell-cell and cell-extracellular matrix interactions. We evaluated the relationship between local expression of ICAM-1 and the circulating level of sICAM-1, and clarified its biological implications. Serum concentrations of sICAM-1 in 94 colorectal cancer patients were determined. Tissue concentrations of sICAM-1 in the tumor, colorectal adenoma, and the normal mucosa were also determined. The expression of ICAM-1 in the tumor was evaluated immunohistochemically. The serum concentration of sICAM-1 in the patients was significantly higher than that in the controls, and the tumor size was the independent pathological factor that was associated with the serum ICAM-1 level. ICAM-1 immunoreactivity was seen intensively in the stromal cells in the tumor. The tissue concentration of sICAM-1 in the normal mucosa was significantly lower than that in the adenoma and the early carcinoma. The tissue concentration of sICAM-1 in the advanced carcinoma significantly decreased in association with the increase in tumor size. This fluctuation of ICAM-1 expression in the tumor was also associated with the metastatic potential even at an early stage of the disease. The tissue ...Continue Reading

References

Oct 1, 1993·Immunology Today·A J Gearing, W Newman

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Citations

Jul 10, 2010·Biochemical and Biophysical Research Communications·Lars MuellerDieter C Broering
Jul 24, 2007·International Journal of Oral and Maxillofacial Surgery·A J Lyons, J Jones
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Yukinobu MaruoKunzo Orita
Mar 28, 2008·Annals of Surgical Oncology·Yuji ToiyamaMasato Kusunoki

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