PMID: 46156Feb 7, 1975

Biological importance of retrograde axonal transport of nerve growth factor in adrenergic neurons

Brain Research
U ParaviciniH Thoenen

Abstract

Previous studies have shown that nerve growth factor (NGF) produces a selective induction of tyrosine hydroxylase (TH) in peripheral adrenergic neurons and that NGF is transported retrogradely with a high selectivity from the adrenergic nerve terminals to the perikaryon. In order to investigate the biological importance of retrograde NGF transport, the following experiments have been performed; (a) effect of NGF on TH activity in superior cervical ganglia (SCG) after unilateral injection into the anterior eye chamber and the submaxillary gland; and (b) effect of systemic injection of NGF on TH activity in SCG after blockage of retrograde axonal transport by axotomy. After unilateral injection of NGF into the anterior eye chamber and submaxillary gland of both 8-10-day-old rats and adult mice, the increase in TH activity in the SCG was considerably larger on the injected than on the non-injected side although the adrenergic neurons supplying the two organs do not account for more than 25% of the total number of adrenergic neurons in the SCG. A direct diffusion mechanism could be excluded by the fact that unilateral local injection of [125 I] produced no significant side difference in the accumulation of radioactivity in the SCG ...Continue Reading

References

Apr 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R Levi-Montalcini
Dec 1, 1992·Pharmacology & Therapeutics·I A Hendry
Dec 1, 1976·General Pharmacology·M A Bisby
Jul 1, 1976·Brain Research Bulletin·W J Freed
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J LuthmanG Jonsson
Mar 26, 2002·Autonomic Neuroscience : Basic & Clinical·Peter G SmithW Hasan
Jan 1, 1988·Eye·W G Unger, J M Butler
Dec 21, 2000·The European Journal of Neuroscience·W Hasan, P G Smith
Nov 24, 1977·The New England Journal of Medicine·W C MobleyE M Shooter
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R Y AndresR A Bradshaw
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J K Brunso-Bechtold, V Hamburger
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A ZimmermannE M Shooter
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M GoedertU Otten
Jan 1, 1990·Journal of Ocular Pharmacology·W G Unger
Feb 26, 1998·American Journal of Respiratory Cell and Molecular Biology·G W HoyleM Friedman
Jul 1, 1994·Reviews in the Neurosciences·S A Scott, K A Crutcher
Jun 1, 1990·Journal of Neurochemistry·M J SavageD J Goldberg
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·F Collins, A Dawson
Mar 17, 2009·Journal of Neurochemistry·Milan MakwanaGenndij Raivich

Citations

Mar 15, 1974·Brain Research·I A HendryL L Iversen
Aug 23, 1974·Brain Research·K StöckelH Thoenen
Jan 1, 1971·Annual Review of Biochemistry·P B Molinoff, J Axelrod
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·W A FrazierR A Bradshaw
Oct 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·V Bocchini, P U Angeletti
Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·H ThoenenR Kettler

Related Concepts

Axonal Transport
Sympathetic Nervous System
Subcutaneous Injections
Nerve Growth Factor
Anterior Chamber of Eye Structure
Nerve Endings
Cytochrome c Group
Organ
Retrograde Axon Cargo Transport
Neurite Outgrowth Factors

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