Biological influence of Hakai in cancer: a 10-year review.

Cancer Metastasis Reviews
Luís A AparicioAngélica Figueroa

Abstract

In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational downregulation of E-cadherin, a major component of adherens junctions in epithelial cells that is characterized as a potent tumor suppressor and is modulated during various processes including epithelial-mesenchymal transition. Recent data have provided evidences for novel biological functional role of Hakai during tumor progression and other diseases. Here, we will review the knowledge that has been accumulated since Hakai discovery 10 years ago and its implication in human cancer disease. We will highlight the different signaling pathways leading to the influence on Hakai and suggest its potential usefulness as therapeutic target for cancer.

References

Apr 16, 1991·Biochimica Et Biophysica Acta·M Stoker, E Gherardi
Nov 1, 1990·The Journal of Cell Biology·K M WeidnerW Birchmeier
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W J GallinB A Cunningham
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·N PeyriérasF Jacob
Oct 1, 1995·Current Opinion in Cell Biology·M Takeichi
Mar 31, 1999·Trends in Biochemical Sciences·G Christofori, H Semb
Jul 14, 1999·The Journal of Cell Biology·T L LeJ L Stow
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Feb 9, 2000·The Journal of Cell Biology·B M Gumbiner
Sep 22, 2000·Trends in Cell Biology·P K JacksonJ D Reimann
Nov 18, 2000·Experimental Cell Research·V Braga
Feb 12, 2002·Nature Cell Biology·Yasuyuki FujitaWalter Birchmeier
May 8, 2002·Nature Reviews. Molecular Cell Biology·Margaret C FrameJohn A Wyke
Jul 27, 2002·Annual Review of Microbiology·Margo A Brinton
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
Oct 26, 2002·Oncogene·Betty Y ChangChristine A Cartwright
Nov 6, 2002·FEBS Letters·Yaron Shav-Tal, Dov Zipori
Mar 15, 2003·Nature Reviews. Cancer·Erik Sahai, Christopher J Marshall
May 1, 1963·The Journal of Cell Biology·M G FARQUHAR, G E PALADE
Jul 16, 2004·Molecular and Cellular Biology·Vidya MamidipudiChristine A Cartwright
Aug 17, 2004·Trends in Cell Biology·David M Bryant, Jennifer L Stow
Sep 24, 2004·Cancer Cell·Rumey Ishizawar, Sarah J Parsons
Oct 19, 2004·Oncogene·Albert B Reynolds, Agnes Roczniak-Ferguson
Nov 24, 2004·Biological Chemistry·Hiroyuki Nakanishi, Yoshimi Takai
Jan 18, 2005·Trends in Cell Biology·Crislyn D'Souza-Schorey
May 11, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Lecuit

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Citations

May 30, 2013·Cellular and Molecular Life Sciences : CMLS·Luis A AparicioAngélica Figueroa
Nov 20, 2012·Journal of Molecular Histology·Maohong CaoQiyun Wu
Jan 4, 2013·PloS One·Vanessa AbellaAngélica Figueroa
Jun 24, 2015·Cancer Letters·Luis A AparicioAngélica Figueroa
Jan 23, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Meng LuHuijie Bian
Mar 18, 2015·Molecular and Cellular Biology·Jonathan A CooperShawn S C Li
Apr 5, 2020·Nature Communications·Song ZhuGuang-Rong Yan
Feb 24, 2018·Scientific Reports·Raquel CastosaAngélica Figueroa
Oct 30, 2020·Cancers·Andrea Rodríguez-AlonsoAngélica Figueroa
Apr 14, 2021·Nature Communications·Yanhua WangDong Yan
May 19, 2021·Archives of Toxicology·Javier De Las RivasAngélica Figueroa
May 29, 2021·Biomarker Research·Fangchao ZhengPeng Yuan
Jun 20, 2021·Nature Communications·Praveen BawankarJean-Yves Roignant

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Methods Mentioned

BETA
ubiquitination
GTPases
2-hybrid
transfection

Software Mentioned

CAM

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