Biological inhibitory effects of the Chinese herb danggui on brain astrocytoma

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
Wei-Hwa LeeAnn Chen

Abstract

Previous studies have demonstrated the utility of the traditional Chinese herb danggui in the treatment of chronic myelogenous leukemia. Our aim was to examine whether it might similarly be used to treat glioblastoma multiforme. The lipid-soluble active ingredients of danggui were extracted with acetone (AS-AC) or chlorophenol (AS-CH) and their antiproliferative and proapoptotic effects were studiedin vitro on cultured GBM 8401 cells and in vivoon tumors in nude mice. After a 24-hour treatment, either AS-AC or AS-CH at a lower (50 micro g/ml) and a higher concentration (100 micro g/ml) significantly inhibited the proliferative activity of GBM 8401 cultured cells by 30-50%, as well as the expression of cathepsin B and vascular endothelial growth factor (VEGF). In nude mice, the growth of the tumor was inhibited by 30% by AS-CH or AS-AC (20 mg/kg; p < 0.05) and by 60% by AS-CH or AS-AC (60 mg/kg; p < 0.05). AS-AC and AS-CH also significantly inhibited microvessel formation in the tumors of nude mice. Danggui may inhibit tumor growth by reducing the level of VEGF and the proapoptotic protein, cathepsin B. Thus, danggui may be useful in the treatment of high-grade astrocytomas.

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Citations

Mar 2, 2011·Molecular Neurobiology·Ramaswamy KannappanBharat Bhushan Aggarwal
Aug 20, 2011·Chinese Medicine·Wen-Wan Chao, Bi-Fong Lin
Oct 26, 2010·Chemico-biological Interactions·Birgit M Dietz, Judy L Bolton
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Lu WangYa-Ping Wang
Dec 9, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui-Fang ChangLing-Ling Yang
May 18, 2019·The American Journal of Chinese Medicine·Fei-Ting HsuJing-Gung Chung
Nov 29, 2017·BioMed Research International·Moon Nyeo ParkBonglee Kim
Mar 18, 2021·Integrative Cancer Therapies·Li-Jeng ChenBor-Show Tzang

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