Abstract
Mycosis fungoides and Sezary syndrome, collectively known as cutaneous T-cell lymphomas (CTCLs), are low-grade, indolent, clonal, non-Hodgkin's lymphomas consisting of CD4+ CD45RO+ T cells with a CLA+ CCR4+ skin-homing phenotype. There are several variants of primary CTCLs with differences in clinical behavior and prognosis. Currently, the precise etiologies of mycosis fungoides and Sezary syndrome are unknown. This article reviews our current understanding of the pathogenetic abnormalities involving genomic mutations, abnormal cDNA expression, and dysregulation of signaling pathways in CTCL.
References
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·Q ZhangM A Wasik
Mar 20, 1999·The Journal of Investigative Dermatology·L KarenkoA Ranki
Feb 13, 2001·The Journal of Investigative Dermatology·L KarenkoA Ranki
Sep 21, 2001·The Journal of Investigative Dermatology·J J ScarisbrickS J Whittaker
Sep 5, 2002·The British Journal of Dermatology·X MaoS J Whittaker
Oct 24, 2002·Blood·Xin MaoSean J Whittaker
Nov 5, 2002·The American Journal of Pathology·Lorraine TraceyMiguel A Piris
Apr 12, 2003·Blood·Lorraine TraceyMiguel A Piris
Apr 16, 2003·Genes, Chromosomes & Cancer·Xin MaoSean Whittaker
Jun 5, 2003·The Journal of Experimental Medicine·Laszlo KariLouise C Showe
Jun 28, 2003·Blood·Nikhil YawalkarThomas S Kupper
Nov 25, 2003·The Journal of Investigative Dermatology·Julia J ScarisbrickSean J Whittaker
Feb 18, 2004·Nature Reviews. Cancer·Hua Yu, Richard Jove
Apr 17, 2004·The Journal of Investigative Dermatology·Tanja C FischerHolger Tönnies
Aug 18, 2004·Cancer Research·Remco van DoornCornelis P Tensen
Oct 30, 2004·Blood·Carole L BergerRichard L Edelson
Nov 13, 2004·Genes, Chromosomes & Cancer·E Mary WainSean J Whittaker
Jul 22, 2005·The British Journal of Dermatology·Robin Russell-Jones
Sep 17, 2005·Cancer Research·Leena KarenkoAnnamari Ranki
Citations
Jul 13, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christiane QuerfeldTimothy M Kuzel
Aug 1, 2014·PloS One·Urs B HagemannSergej M Kiprijanov
Oct 24, 2008·The British Journal of Dermatology·M B WozniakR Villuendas Deceased
Apr 21, 2012·Journal of Cutaneous Pathology·Meghali GoswamiXiao Ni
Jun 12, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I VergoteUNKNOWN ASSIST-1 Study Group
Apr 2, 2020·Expert Opinion on Therapeutic Patents·Vanessa HallerStefan A Laufer
Jul 14, 2020·SAGE Open Medical Case Reports·James DotimasDaniel Martin
Mar 28, 2007·Cancer Control : Journal of the Moffitt Cancer Center·Connie A KeehnL Frank Glass
Jul 17, 2016·Cancer Discovery·Anjali MishraMichael A Caligiuri
Mar 7, 2021·Journal of Cutaneous Pathology·Carlo TomasiniPietro Quaglino