Biological insights into the pathogenesis of cutaneous T-cell lymphomas (CTCL)

Seminars in Oncology
Sean Whittaker

Abstract

Mycosis fungoides and Sezary syndrome, collectively known as cutaneous T-cell lymphomas (CTCLs), are low-grade, indolent, clonal, non-Hodgkin's lymphomas consisting of CD4+ CD45RO+ T cells with a CLA+ CCR4+ skin-homing phenotype. There are several variants of primary CTCLs with differences in clinical behavior and prognosis. Currently, the precise etiologies of mycosis fungoides and Sezary syndrome are unknown. This article reviews our current understanding of the pathogenetic abnormalities involving genomic mutations, abnormal cDNA expression, and dysregulation of signaling pathways in CTCL.

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Citations

Jul 13, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christiane QuerfeldTimothy M Kuzel
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