Biological interaction of cigarette smoking on the association between genetic polymorphisms involved in inflammation and the risk of lung cancer: A case-control study in Japan

Oncology Letters
Yuzo YamamotoYoichi Nakanishi

Abstract

Chronic inflammation serves an important role in lung carcinogenesis, thus genetic polymorphisms involved in this pathway may affect the risk of lung cancer. The present case-control study focused on the association between lung cancer risk and genetic polymorphisms involved in inflammatory pathways. The study comprised 462 lung cancer cases and 379 controls from Japan. The roles of interleukin 8 (IL8) rs4073, nuclear factor kappa B (NFκB) rs28362491, cytochrome b-245, alpha polypeptide (CYBA) rs4673, NAD(P) H dehydrogenase, quinone 1 (NQO1) rs1800566, nitric oxide synthase 2 and inducible (NOS2) rs2297518 polymorphisms in lung carcinogenesis were investigated. An unconditional logistic model was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for the association between the genetic polymorphisms and lung cancer risk. The multiplicative and additive [relative excess risk due to interaction, attributable proportion due to interaction (AP) and synergy index (SI)] interactions with cigarette smoking were also determined. A significant association was revealed between the TT genotype of NQO1 rs1800566 and an increased risk of lung cancer (OR=1.78; 95% CI=1.14-2.79). The additive interaction evaluations between...Continue Reading

References

Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·P Joseph, A K Jaiswal
Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·H TakizawaA Umeda
Sep 7, 2001·Cytokine & Growth Factor Reviews·K Xie
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Apr 3, 2003·Nature Reviews. Cancer·S Perwez HussainCurtis C Harris
Apr 3, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Edgar A JaimesLeopoldo Raij
Aug 27, 2005·European Journal of Epidemiology·Tomas AnderssonAnders Ahlbom
Oct 11, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Daniele CampaFederico Canzian
Nov 15, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ayumu TaguchiHidemi Goto
Dec 13, 2005·American Journal of Epidemiology·Lindsay M MortonPatricia Hartge
Jul 11, 2006·Journal of Gastroenterology and Hepatology·Kennosuke ShiraiHidemi Goto
Jan 11, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Zsuzsanna OroszZoltan Ungvari
Jul 3, 2007·Free Radical Biology & Medicine·J David Lambeth
Oct 6, 2007·Chest·Anthony J AlbergUNKNOWN American College of Chest Physicians
Apr 12, 2008·Expert Review of Anticancer Therapy·Eric A Engels
Apr 15, 2008·Cancer Letters·Masuko Ushio-Fukai, Yoshimasa Nakamura
Sep 30, 2008·Journal of Cancer Research and Clinical Oncology·Auemduan PrawanVeerapol Kukongviriyapan
Dec 29, 2009·Current Opinion in Genetics & Development·Sergei I Grivennikov, Michael Karin
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Apr 7, 2010·Archives of Biochemistry and Biophysics·Albena T Dinkova-Kostova, Paul Talalay
Apr 28, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediEric A Engels
Dec 14, 2011·Molecular Biology Reports·Wen-Jia PengJing Wang
Jan 11, 2012·Circulation. Cardiovascular Genetics·Audrey Y ChuPaul M Ridker
Jun 5, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Marisa L MeyerJudith A Voynow
Jul 16, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuqing LouBaohui Han
Apr 8, 2014·BioMed Research International·Y M OltuluI Yaylim

❮ Previous
Next ❯

Citations

Jul 6, 2021·Expert Review of Clinical Immunology·Kaiyue DingYuan Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.