PMID: 42796Nov 1, 1979

Biological investigations in alcohol research

Journal of Studies on Alcohol. Supplement
B Kissin

Abstract

The biological mechanisms examined in this paper cover only a small portion of those that may be involved in the pathogenesis of alcoholism. Certain areas on which a great deal of work has already been done have been entirely omitted. Among these are studies on brain acetylcholine and gamma-aminobutyric acid metabolism in alcohol-related conditions; the effect of alcohol on brain proteins and nucleotides and the relationship of changes in these to the development of tolerance and physical dependence; and a variety of other areas involving biochemical and physiological parameters. The omission of any of these areas in no way suggests that they are less significant than those that have been covered. It is just that I have attempted to present a cohesive and coherent review of some areas of biological research which thus far appear to throw light on the clinical development and phenomenology of the alcoholism syndrome. In order to present such a thesis, I have inevitably crowded the evidence to fit some of my pet hypotheses. However, in controversial areas (which are many), I have tried to present some of the evidence on both sides and, hopefully, have succeeded in offering a fair overview of the state of the science as it exists ...Continue Reading

Citations

Jun 6, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hans M OlbrichBernd Feige
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·P R MartinM J Eckardt
Mar 1, 1986·Alcohol·D Butler, F S Messiha
Mar 1, 1984·Alcohol·G Freund
Mar 28, 2008·Substance Use & Misuse·G MartinottiL Janiri
Feb 1, 1987·Experimental Neurology·J N NobregaV Rakoff
May 1, 1981·Developmental Psychobiology·R A Schreiber, A Lehmann
Oct 6, 2016·Alcoholism, Clinical and Experimental Research·Subhajit ChakravortyKirk J Brower
Feb 1, 1997·Alcoholism, Clinical and Experimental Research·T I MuellerP R Recupero
Jan 9, 2007·Alcoholism, Clinical and Experimental Research·Bernd FeigeDieter Riemann
Jan 1, 1981·Alcoholism, Clinical and Experimental Research·D W WalkerW C Abraham
Oct 1, 1989·Alcoholism, Clinical and Experimental Research·C B De SotoJ L De Soto
Feb 24, 2006·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Michael D Stein, Peter D Friedmann
Nov 19, 1981·The New England Journal of Medicine·E M SellersJ E Peachey
Sep 1, 1981·British Journal of Addiction·U GolükeD Meadows

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