PMID: 6980699Oct 1, 1982Paper

Biological markers and breast cancer. A multiparametric study. II. Depressed immune competence

Cancer
R MandevilleR Poisson

Abstract

Immune functions were evaluated in 207 carefully staged breast cancer patients, 54 patients with benign breast diseases and 152 normal controls. All patients were followed for at least five years and the prognostic significance of immune competence determined at diagnosis was established. The parameters employed were dermal hypersensitivity to four skin test antigens and to 2,4-dinitrochlorobenzene (DNCB), blastogenic responses to PHA (phytohemagglutinin), ConA (Concanavalin A), and PW (Pokeweed mitogen) mitogens and percentage of T- and B-lymphocytes. A significant degree of impairment of immune functions was found in breast cancer patients when compared to controls; this was illustrated by depressed T-cell counts and low responses to PHA, ConA and PW mitogens and by depressed responses to recall antigens. However, only lymphocyte stimulation with PHA, percentage of T-cells and dermal hypersensitivity tests showed a continued decrease with advancing stages of the disease. Moreover, among cancer patients with low responses to recall antigens, 61% died before five years, 16% showed progressive disease and only 22% were disease-free after five years of follow-up; compared to 30, 18 and 52%, respectively, in patients with normal r...Continue Reading

References

Apr 1, 1975·The Journal of Allergy and Clinical Immunology·J GrossmanJ J Condemi
May 15, 1977·International Journal of Cancer. Journal International Du Cancer·M ZembalaG L Asherson
May 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H Kirchner
Jan 24, 1976·British Medical Journal·G LamoureuxM Desrosiers
Jan 1, 1976·Annals of the New York Academy of Sciences·E M HershR G Vincent
Feb 27, 1975·The New England Journal of Medicine·R L GrossP M Newberne
Jan 9, 1971·Lancet·S K ParkW S Blakemore
Jul 30, 1972·Bollettino della Società italiana di biologia sperimentale·G S Del GiaccoV Grifoni
Jan 1, 1972·The American Journal of Medicine·R C YoungV T DeVita
Nov 1, 1965·Journal of Clinical Pathology·R E Millard
Nov 4, 1965·The New England Journal of Medicine·E M Hersh, J J Oppenheim
Mar 31, 1964·Annals of the New York Academy of Sciences·G W SANTOSL L SENSENBRENNER
Jan 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·J Hájek

❮ Previous
Next ❯

Citations

Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·M NielsenJ A Andersen
Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·R ValavaaraA Toivanen
Jul 9, 2002·The Breast Journal·Liron Pantanowitz, James L Connolly
Jan 1, 1994·Cancer Investigation·E M Greenspan
Aug 1, 1985·Pathology, Research and Practice·M A Sobrinho-SimõesA Giesteira-Almeida
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sahar M A MahmoudAndrew R Green
Mar 17, 2004·Psycho-oncology·Richard H OsborneAndrew J Sinclair
Jan 1, 1985·Acta geneticae medicae et gemellologiae·H Anton-GuirgisR Elston
Nov 1, 1991·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·S SzmigielskiZ Petrovich
Mar 28, 2001·Annals of the New York Academy of Sciences·S Greer
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Keren ShakharDana H Bovbjerg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.