PMID: 6122762Jun 1, 1982

Biological markers as an aid in the clinical management of patients with liver metastases

Journal of Surgical Oncology
T P WaalkesW D Bostick


Liver metastases due to the more common neoplastic diseases such as colorectal, breast, or bronchogenic carcinoma are a frequent occurrence and are associated with an ominous prognosis. Earlier detection followed by appropriate therapeutic interventions might have a decided effect on the subsequent course of disease. Controversy exists over the selection of tests with the greatest sensitivity, specificity, and potential utility. Preliminary evidence suggest that gamma-glutamyl transpeptidase and 5'-nucleotidase may be of particular significance. Four enzymes--gamma-glutamyl transpeptidase, 5'-nucleotidase, leucine aminopeptidase, and alkaline phosphatase plus carcinoembryonic antigen--were compared in the same blood samples from selected patients with breast and small cell carcinoma of the lung. Gamma-Glutamyl transpeptidase was the most sensitive test with 28/29 (97%) patients with hepatic metastases having elevated enzymatic activity in their sera. For patients with small cell carcinoma of the lung followed serially, gamma-glutamyl transpeptidase activity was increased an average of 5 months before liver metastases were detected by clinical means. Two factors are important in the interpretation of the results of gamma-glutamy...Continue Reading


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Related Concepts

Alkaline Phosphatase
Mammary Neoplasms, Human
Carcinoembryonic Antigen
Malignant Tumor of Colon
Gamma-glutamyl transferase
Methoxyleucine Aminopeptidase
Malignant Neoplasm of Liver
Malignant Neoplasm of Lung
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