Biological monitoring of exposure to 1,5-naphthalene diisocyanate and 4,4'-methylenediphenyl diisocyanate

International Archives of Occupational and Environmental Health
Carl Johan SennbroH Tinnerberg

Abstract

Biological monitoring of occupational sensitizers, such as 1,5-naphthalene diisocyanate (NDI) and 4,4'-methylenediphenyl diisocyanate (MDI) is of high importance. In this study, 1,5-naphthalenediamine (NDA) and 4,4'-methylenedianiline (MDA) in hydrolysed urine and plasma were evaluated as biomarkers of exposure to NDI and MDI, respectively. The air exposure to NDI and MDI was monitored for 30 exposed workers at four different plants. In parallel, urinary as well as blood plasma samples were collected. Biomarker levels were determined in hydrolysed urine and plasma by means of gas chromatography-mass spectrometry. Air exposure to both MDI and NDI was correlated to their corresponding urinary and plasma biomarkers. The correlation coefficients for the associations between air and biomarker levels were in the range of 0.51-0.65 and 0.53-0.96 for MDI and NDI, respectively. For NDI, but not for MDI, the significance and correlation coefficients were increased by adjusting the urinary biomarker levels for creatinine content or density. Biomarker and air levels of MDI and NDI were correlated, but there was a large individual variation.

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Citations

Feb 24, 2011·Journal of Environmental Monitoring : JEM·Kirsi SäkkinenChristina Rosenberg
Sep 29, 2009·The Annals of Occupational Hygiene·I LiljelindL A Nylander-French
Oct 7, 2009·The Annals of Occupational Hygiene·Sheila L FlackLeena A Nylander-French
Jun 10, 2010·The Annals of Occupational Hygiene·Linda G T GainesLeena A Nylander-French
Jan 22, 2011·The Annals of Occupational Hygiene·John Cocker
Mar 14, 2007·Current Opinion in Allergy and Clinical Immunology·Adam V Wisnewski
Apr 6, 2013·International Archives of Occupational and Environmental Health·Håkan TinnerbergBo A G Jönsson
Mar 27, 2012·Environmental Toxicology and Pharmacology·Atif KamalAudil Rashid
Dec 29, 2013·Journal of Occupational and Environmental Hygiene·Angela R LemonsBrett J Green
Jul 14, 2010·Human & Experimental Toxicology·Olga GioulemeDimitrios Koliouskas
Apr 22, 2020·Annals of Work Exposures and Health·Bernice ScholtenKate Jones

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