Biological monitoring of exposure to organophosphorus insecticides in a group of horticultural greenhouse workers

The Annals of Occupational Hygiene
Michèle BouchardNolwenn Noisel

Abstract

Exposure to selected organophosphorus insecticides (OPs), malathion, diazinon and acephate, was evaluated in a group of horticultural greenhouse workers. This was achieved through measurements of the cumulative urinary excretion time courses of specific and non-specific biomarkers over a 24 h period following the onset of work exposure. For malathion, the absorbed daily doses were estimated from the 24 h cumulative urinary amounts of the specific mono- and di-carboxylic acid metabolites (the sum of MCA and DCA) through the use of a kinetic model. The observed 24 h urinary levels were also compared with a biological reference value (BRV) of 57 nmol kg(-1) of body weight established in a previous work on the basis of a human no-observed-effect level exposure dose. Excretion values were found to be 2.5% or less of the BRV, suggesting a negligible health risk. Both median and 95th percentile concentrations of DCA (n = 57 samples) were, however, slightly higher than the baseline values determined by the Centers for Disease Control and Prevention (CDC) in the US civilian population (MCA was not analyzed by the CDC). The cumulative urinary excretion time course of the methyl phosphoric (MP) derivatives, which are metabolites of malath...Continue Reading

Citations

Nov 6, 2008·Environmental Health : a Global Access Science Source·Marie-Chantale FortinMichèle Bouchard
Feb 21, 2009·Environmental Health : a Global Access Science Source·Mathieu Valcke, Michèle Bouchard
Mar 24, 2009·Journal of Occupational and Environmental Hygiene·Caroline CoutureMichèle Bouchard
May 1, 2010·Environmental Toxicology and Pharmacology·Nolwenn NoiselGaétan Carrier
Feb 28, 2018·International Journal of Occupational and Environmental Health·Clemente Aguilar-GarduñoMarina Lacasaña
Jul 3, 2019·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Yonatal Mesfin TeferaSharyn Gaskin
Apr 15, 2010·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Manel AraoudAbderraouf Kenani

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