Biological Motion Perception, Brain Responses, and Schizotypal Personality Disorder

JAMA Psychiatry
Ji-Won HurJun Soo Kwon

Abstract

Exploration of the ability to process socially relevant events portrayed by biological motion and to identify underlying neuronal processes can provide clues for understanding the pathophysiology of psychosis. Individuals with schizotypal personality disorder (SPD) have pervasive interpersonal deficits and odd behaviors. An understanding of the neural mechanisms involved in the perception of biological motion and the relation of activity to clinical symptoms in those mechanisms is needed. To investigate the specificity of brain regions responsive to biological motion perception in individuals with SPD compared with healthy control individuals. Twenty-one patients diagnosed as having SPD and 38 age-, sex-, and IQ-matched controls underwent event-related functional magnetic resonance imaging. The SPD group completed the Scale for the Assessment of Positive Symptoms, the Scale for the Assessment of Negative Symptoms, and the Schizotypal Personality Questionnaire for assessment of symptom severity. During scanning, all participants were required to discriminate biological from scrambled sequences of point-light animations. Data were collected from September 21. 2011, to July 13, 2013, and analyzed from March to May 2015. Blood oxyg...Continue Reading

Citations

Nov 18, 2018·Social Cognitive and Affective Neuroscience·So-Yeon KimSoo-Hee Choi
Oct 1, 2016·Journal of Neuroscience Research·Marina A Pavlova
Mar 3, 2020·Frontiers in Psychology·Seoyeon KwakJun Soo Kwon
Aug 18, 2018·Annals of General Psychiatry·Athanasios ApostolopoulosAthanasios Douzenis
Mar 3, 2020·Frontiers in Psychology·Sara IserniaMarina A Pavlova
Sep 2, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Oskar ZarnowskiGabriela Santos-Nunez

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