Biological performance of biodegradable amino acid-based poly(ester amide)s: Endothelial cell adhesion and inflammation in vitro

Journal of Biomedical Materials Research. Part a
Joshua A HorwitzCynthia A Reinhart-King

Abstract

Functionalized amino-acid-based poly(ester-amide)s (PEA) are a new family of synthetic biodegradable polymers consisting of three naturally occurring building blocks (amino acids, diols, and dicarboxylic acids) that have been suggested to be promising biomaterials for therapeutic use. However, little is known about their cytotoxicity, ability to support cell growth, inflammatory properties, or mechanical properties, key aspects to most biomaterials designed for in vivo implantation and tissue engineering applications. In this study, we investigated the ability of two functionalized PEA materials (amino-functionalized and carboxylic acid functionalized) and a neutral PEA control to support endothelial cell viability, proliferation, and adhesion. Additionally, we investigated the inflammatory response elicited by these functionalized PEA materials using a macrophage cell model. Our results indicate that all forms of PEA were noncytotoxic and noninflammatory in vitro. The amino-functionalized PEA bests supports endothelial cell adhesion, growth, and monolayer formation. Mechanical testing indicates that the elastic moduli of these materials are strongly dependent on the charge formulation, but do exhibit linearly elastic behavior ...Continue Reading

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Citations

Jun 12, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Karina A HernandezJason A Spector
Apr 29, 2014·Acta Biomaterialia·Darryl K KnightKibret Mequanint
Jul 20, 2011·Journal of Polymer Science. Part B, Polymer Physics·Bret D UleryCato T Laurencin
Feb 27, 2014·Journal of Biomaterials Science. Polymer Edition·Shimon LechtPeter I Lelkes
Feb 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·J LiuC C Chu
Jan 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jun Wu, Chih-Chang Chu

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