Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans

Psychoneuroendocrinology
Esther M BlessingCharles R Marmar

Abstract

Posttraumatic stress disorder (PTSD) is associated with increased risk for Type 2 diabetes and cardiovascular disease (cardiometabolic disease), warranting research into targeted prevention strategies. In the present case-control study of 160 young (mean age 32.7 years) male military veterans, we aimed to assess whether PTSD status predicted increased markers of cardiometabolic risk in otherwise healthy individuals, and further, to explore biological pathways between PTSD and these increased markers of cardiometabolic risk. Toward these aims, we compared measures of cardiometabolic risk, namely insulin resistance (IR) (HOMA-IR), metabolic syndrome (MetS) and prediabetes, between 80 PTSD cases and 80 controls without PTSD. We then determined whether PTSD-associated increases in HOMA-IR were correlated with select biological variables from pathways previously hypothesized to link PTSD with cardiometabolic risk, including systemic inflammation (increased C-reactive protein, interleukin-6, and tumor necrosis factor α), sympathetic over-activity (increased resting heart rate), and neuroendocrine dysregulation (increased plasma cortisol or serum brain-derived neurotrophic factor (BDNF)). We found PTSD diagnosis was associated with su...Continue Reading

References

May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Nov 19, 2003·Annals of Internal Medicine·Tracey McLaughlinGerald Reaven
Aug 8, 2006·Annals of the New York Academy of Sciences·Nnamdi Pole
Oct 17, 2006·Psychiatry·Dorie A GloverRussell E Poland
Oct 20, 2006·Psychoneuroendocrinology·Julia A GolierRachel Yehuda
Aug 6, 2009·JAMA : the Journal of the American Medical Association·Beth E CohenKaren H Seal
Feb 23, 2010·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Eric A DedertJean C Beckham
May 3, 2011·The American Journal of Cardiology·Naser AhmadiRamin Ebrahimi
Jun 14, 2013·Metabolic Syndrome and Related Disorders·Francesco BartoliMassimo Clerici
Jul 3, 2013·Journal of the American College of Cardiology·Viola VaccarinoJ Douglas Bremner
Oct 26, 2013·Cardiology·Arlene Bradley LevineT Barry Levine
Nov 2, 2013·American Heart Journal·Donald EdmondsonMatthew M Burg
Dec 12, 2013·Molecular Metabolism·Sudarshana Purkayastha, Dongsheng Cai
Jun 15, 2014·Brain, Behavior, and Immunity·Daniel LindqvistFirdaus S Dhabhar
Sep 18, 2014·The New England Journal of Medicine·Gerald I Shulman
Mar 17, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·O M FarrC S Mantzoros
May 15, 2015·Journal of Diabetes and Metabolic Disorders·Andrew GrandinettiJoseph Keawe'aimoku Kaholokula
Jul 15, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K W ter HorstM J Serlie
Feb 13, 2016·Psychosomatic Medicine·Davy VancampfortBrendon Stubbs
Mar 26, 2016·World Journal of Psychiatry·Lei ZhangXian-Zhang Hu
Apr 12, 2016·Molecular and Cellular Endocrinology·Wei LiuLinong Ji
Jun 2, 2016·Experimental Neurology·Vasiliki MichopoulosGretchen Neigh

❮ Previous
Next ❯

Citations

Mar 19, 2019·PloS One·Synthia H MellonOwen M Wolkowitz
Aug 31, 2017·Current Psychiatry Reports·Erika J Wolf, Filomene G Morrison
Feb 6, 2020·Stress : the International Journal on the Biology of Stress·Leigh Luella van den HeuvelSoraya Seedat
Aug 2, 2019·Current Diabetes Reports·Dora Lendvai WischikRobin Whittemore
Apr 22, 2018·World Journal of Pediatrics : WJP·Timothy R RiceLeo Sher
Jul 7, 2019·Journal of Clinical Medicine·Min Young LeeLeroy Hood
Aug 20, 2019·Frontiers in Neuroendocrinology·Gilmara Gomes de Assis, Eugene V Gasanov
Apr 10, 2018·Biological Psychiatry·Synthia H MellonOwen M Wolkowitz
Nov 6, 2018·Behaviour Research and Therapy·Angelos-Miltiadis KrypotosIris M Engelhard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.