Biological processes and signal transduction pathways regulated by the protein methyltransferase SETD7 and their significance in cancer.

Signal Transduction and Targeted Therapy
Inês de Albuquerque Almeida Batista, Luisa Alejandra Helguero

Abstract

Protein methyltransferases have been shown to methylate histone and non-histone proteins, leading to regulation of several biological processes that control cell homeostasis. Over the past few years, the histone-lysine N-methyltransferase SETD7 (SETD7; also known as SET7/9, KIAA1717, KMT7, SET7, SET9) has emerged as an important regulator of at least 30 non-histone proteins and a potential target for the treatment of several human diseases. This review discusses current knowledge of the structure and subcellular localization of SETD7, as well as its function as a histone and non-histone methyltransferase. This work also underlines the putative contribution of SETD7 to the regulation of gene expression, control of cell proliferation, differentiation and endoplasmic reticulum stress, which indicate that SETD7 is a candidate for novel targeted therapies with the aim of either stimulating or inhibiting its activity, depending on the cell signaling context.

References

Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·K OhtaniJ R Nevins
Feb 1, 1997·Molecular Biology of the Cell·L Connell-CrowleyD W Goodrich
Dec 30, 1999·Nature Genetics·F FuksT Kouzarides
Aug 30, 2000·Nature·C M PerouD Botstein
Dec 1, 2000·Biochemical and Biophysical Research Communications·M KanaiM Miwa
Mar 15, 2001·Current Opinion in Cell Biology·G L Semenza
Nov 1, 2002·Molecular Cell·Eva GrönroosJohan Ericsson
Dec 11, 2002·The Journal of Biological Chemistry·Hiromichi Kimura, Kunio Shiota
Jan 23, 2003·Carcinogenesis·Paul M Campbell, Moshe Szyf
May 27, 2003·Nature Cell Biology·Natalia PediconiMassimo Levrero
Jul 12, 2003·Science·Diego H CastrillonRonald A DePinho
Jul 31, 2003·Molecular Cell·Xing ZhangXiaodong Cheng
Jul 31, 2003·Nucleic Acids Research·Helena Santos-RosaMarian Martínez-Balbás
Apr 22, 2004·Molecular Cell·Antigone KouskoutiIannis Talianidis
Jun 9, 2004·Nature Genetics·Jun MukaiJoseph A Gogos
Jul 23, 2004·Current Biology : CB·Craig L Peterson, Marc-André Laniel
Aug 28, 2004·Nature Structural & Molecular Biology·Attila ReményiMatthias Wilmanns
Sep 24, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Xiang-Jiao Yang
Nov 5, 2004·Nature·Sergei ChuikovDanny Reinberg
Nov 25, 2004·Progress in Biophysics and Molecular Biology·Paul A NguewaJosé M Pérez
Dec 2, 2004·Nature Reviews. Molecular Cell Biology·Wei Wong, John D Scott
May 3, 2005·Nature Reviews. Drug Discovery·Prakash Jagtap, Csaba Szabó
Jun 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Matthew G GuentherRichard A Young
Sep 6, 2005·The Journal of Biological Chemistry·Joshua FrancisRaghavendra G Mirmira
Sep 13, 2005·Cell·Laurie A BoyerRichard A Young
Sep 21, 2005·Journal of Cellular Biochemistry·Ke Zhang, Sharon Y R Dent
Nov 2, 2005·Nature Reviews. Molecular Cell Biology·Cyrus Martin, Yi Zhang
Dec 6, 2005·Trends in Genetics : TIG·Richard Morgan
Jan 18, 2006·Nature Structural & Molecular Biology·Jean-François CoutureRaymond C Trievel

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Citations

Oct 2, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Silvia BrichSilvana Pilotti
Dec 13, 2019·Journal of Receptor and Signal Transduction Research·Yunpeng TianHaoming Song
Dec 21, 2019·Journal of Receptor and Signal Transduction Research·Yang YangZhiyun Wang
Jan 29, 2020·Journal of Receptor and Signal Transduction Research·Peng LiQiuyun Tu
Aug 23, 2019·World Journal of Gastrointestinal Oncology·Si-Si LiRong Wan
Oct 16, 2019·Journal of Cellular Physiology·Dezhi Huang, Yugang Jiang
Nov 23, 2019·Journal of Receptor and Signal Transduction Research·Guanqun Ma, Yingwu Liu
Aug 4, 2019·The Journal of Investigative Dermatology·Mariana Basso SpadoniAngelica Beate Winter Boldt
Jan 3, 2020·Current Protein & Peptide Science·Valentina LukinovićNicolas Reynoird
Apr 30, 2019·Journal of the American Chemical Society·Shi ChenMinkui Luo

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Methods Mentioned

BETA
ubiquitination
nuclear translocation
acetylation

Software Mentioned

STRING

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