Biological prognostic and predictive factors in lung cancer

Oncology
Antonio RossiCesare Gridelli

Abstract

The inclusion of new drugs in clinical research and practice has allowed improvements in several outcomes of advanced non-small-cell lung cancer (NSCLC). Among these drugs, very interesting results have been obtained from pemetrexed and new targeted agents, including the inhibitors of epidermal growth factor receptor (EGFR) such as gefitinib, erlotinib and cetuximab. Unfortunately, these new drugs when investigated for the treatment of small-cell lung cancer (SCLC) reported negative results. The results of these investigations seem to be related to specific factors that could indicate which patients could benefit from each specific therapy. Therefore, several clinical and biological factors might find use as prognostic or predictive markers. A prognostic factor provides information on outcome, independent of the therapy that is used. In contrast, a predictive factor provides information on outcome with regard to a specific therapy. Some factors, such as EGFR mutations, are both prognostic and predictive. In the present paper, we review data related to thymidylate synthase, EGFR and K-ras mutations, the most important biologic prognostic and/or predictive factors related to pemetrexed, gefitinib, erlotinib and cetuximab therapy ...Continue Reading

Citations

Aug 27, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hiroyuki Kaneda, Yukihito Saito
May 26, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Razvan DiaconescuRenaud Whittom
Nov 11, 2010·Clinical Lung Cancer·Cesare GridelliPaola Claudia Sacco
May 28, 2011·International Journal of Cancer. Journal International Du Cancer·Paolo CeppiGiorgio V Scagliotti
Dec 15, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hongxia MaYongqian Shu
Apr 9, 2013·The Journal of Molecular Diagnostics : JMD·Neal I Lindeman College of American Pathologists International Association for the Study of Lung Cancer and Association for Molecular Pathol
Jun 16, 2016·Oncotarget·Maximilian NiyaziKristian Unger
Oct 1, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert J CardnellLauren A Byers

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