PMID: 9429214Jan 1, 1997Paper

Biological properties of interleukin-12 and its therapeutic use in persistent hepatitis B virus and hepatitis C virus infection

Journal of Viral Hepatitis
V Carreno, J A Quiroga

Abstract

Interleukin (IL)-12 is a pleiotropic cytokine produced by antigen-presenting cells in response to diverse stimuli. IL-12 is a key molecule in the regulation of host's immune responses. In particular, IL-12 influences the balance between the T-helper cells type 1 (TH1) and type 2 (TH2); it modulates macrophage responses through the control of interferon-gamma synthesis by TH1 cells; and, suppresses IgE class antibody production (has a suppressive effect on allergic reactions) and promotes a shift in the IgG subclasses. IL-12 enhances resistance to several infectious diseases, is a powerful antitumor agent in vivo, and acts as a vaccine adjuvant. The biological properties of IL-12 point to the potential therapeutic use in persistent hepatitis B virus and hepatitis C virus infection.

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Citations

Dec 30, 1999·Clinical Biochemistry·M G NeumanP Marcellin
Mar 12, 2008·Infection and Immunity·Sanbao RuanJudd E Shellito
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K J O'ByrneA L Harris
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordan FeldStephen Locarnini
May 28, 2005·Intervirology·Mitsuhiko MoriyamaYasuyuki Arakawa
Jan 11, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·UNKNOWN Arbeitskreis Blut des Bundesministeriums für Gesundheit
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Dec 29, 1998·Antiviral Chemistry & Chemotherapy·J MainH C Thomas
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G C Pien, C A Biron

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