Biological rationales and clinical applications of temperature controlled hyperthermia--implications for multimodal cancer treatments

Current Medicinal Chemistry
Petra SchildkopfUdo S Gaipl

Abstract

Hyperthermia (HT)--heating the tumor in the range of 40.0- 44.0 °C--combined with radiation (RT) and/or chemotherapy (CT) is a well proven treatment for malignant tumors. The improvement of the techniques for monitoring and adapting of the desired temperatures even in deep seated tumors has led to a renaissance of, now quality-controlled, HT in multimodal tumor therapy approaches. Randomized clinical trials have shown improved disease-free survival and local tumor control without an increase in toxicity for the combined treatment. In this review, we will focus on biological rationales of HT comprising direct cytotoxicity, systemic effects, chemosensitization, radiosensitization, and immune modulation. The latter is a prerequisite for the control of recurrent tumors and micrometastases. Immunogenic tumor cell death forms induced by HT will be introduced. Modulations of the cytotoxic properties of chemotherapeutic agents by HT as well as synergistic effects of HT with RT will be presented in the context of the main aims of anti-tumor therapy. Furthermore, modern techniques for thermal mapping like magnet resonance imaging will be outlined. The effectiveness of HT will be demonstrated by reviewing recent clinical trials applying H...Continue Reading

Citations

Apr 19, 2011·International Journal of Nanomedicine·Héctor L Rodríguez-LuccioniMadeline Torres-Lugo
Sep 22, 2012·Nanomedicine·Ingrid Hilger, Werner A Kaiser
Oct 17, 2014·Nanomedicine·Takeshi KobayashiKowichi Jimbow
Feb 11, 2014·International Journal of Heat and Mass Transfer·D B RodriguesP F Maccarini
Oct 21, 2010·Annals of the New York Academy of Sciences·Eva-Maria WeissUdo S Gaipl
Jan 14, 2012·Clinical & Developmental Immunology·Sebastian P HaenCécile Gouttefangeas
Sep 12, 2015·Apoptosis : an International Journal on Programmed Cell Death·Kanwal AhmedTakashi Kondo
Oct 31, 2014·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Imen Belhadj SlimenManef Abdrabbah
Jun 14, 2012·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Benjamin FreyUdo S Gaipl
Oct 15, 2014·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Niloy R DattaStephan Bodis
Jun 28, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Petra SchildkopfUdo S Gaipl
May 26, 2016·Expert Opinion on Drug Delivery·Dawn Bannerman, Wankei Wan
Sep 22, 2018·Immunotherapy·Yang LiuTuan Vo-Dinh
Jan 19, 2020·Cancer Immunology, Immunotherapy : CII·Michael HaderUdo S Gaipl
Feb 3, 2011·Advanced Materials·Séverine BruléCatherine Le Visage
Nov 13, 2018·Bladder Cancer·Molly A IngersollRosalyn M Adam
May 1, 2021·Journal of the American Chemical Society·Jiong PanJianlin Shi
May 1, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Wen-Hsuan ChiangHsin-Cheng Chiu
Jun 13, 2015·ACS Applied Materials & Interfaces·Chunyan XuZhechuan Mei
Nov 8, 2018·ACS Applied Materials & Interfaces·Minghua LiPeijun Wang

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