Biological Regeneration of Articular Cartilage in an Early Stage of Compartmentalized Osteoarthritis: 12-Month Results

The American Journal of Sports Medicine
M SchinhanR Windhager

Abstract

Biological regeneration in an early stage of osteoarthritis (OA) is an important clinical challenge. An early-stage compartmentalized OA model was used to evaluate different biological regeneration techniques. Biological regeneration in an early stage of compartmentalized OA is possible. Controlled laboratory study. A 7-mm cartilage defect was surgically created in 24 sheep. After 3 months, by which time early OA had set in, the sheep were randomized into 4 different treatment groups and operated for the second time. One group (CONTROL) served as a long-term follow-up group for the further development of OA. The other 3 groups (regeneration groups) each underwent a different regeneration procedure after abrasion of the subchondral bone (defect size: 20 × 10 mm with a depth of 2.5 mm): spongialization alone (SPONGIO), spongialization followed by implantation of an unseeded hyaluronan matrix (MATRIX), or spongialization followed by implantation of a hyaluronan matrix seeded with autologous chondrocytes (MACT). Then, 12 months after the second operative procedure, the animals were euthanized and the defects subjected to macroscopic and histological grading. Historical 4-month data were compared with the 12-month results. After 12 ...Continue Reading

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Citations

Feb 20, 2021·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Francesca VanniniCesare Faldini

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Methods Mentioned

BETA
biopsy
dissection

Software Mentioned

SPSS
SPONGIO
MACT
MATRIX

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