Biological response to prosthetic debris

World Journal of Orthopedics
Diana Bitar, Javad Parvizi

Abstract

Joint arthroplasty had revolutionized the outcome of orthopaedic surgery. Extensive and collaborative work of many innovator surgeons had led to the development of durable bearing surfaces, yet no single material is considered absolutely perfect. Generation of wear debris from any part of the prosthesis is unavoidable. Implant loosening secondary to osteolysis is the most common mode of failure of arthroplasty. Osteolysis is the resultant of complex contribution of the generated wear debris and the mechanical instability of the prosthetic components. Roughly speaking, all orthopedic biomaterials may induce a universal biologic host response to generated wear débris with little specific characteristics for each material; but some debris has been shown to be more cytotoxic than others. Prosthetic wear debris induces an extensive biological cascade of adverse cellular responses, where macrophages are the main cellular type involved in this hostile inflammatory process. Macrophages cause osteolysis indirectly by releasing numerous chemotactic inflammatory mediators, and directly by resorbing bone with their membrane microstructures. The bio-reactivity of wear particles depends on two major elements: particle characteristics (size, ...Continue Reading

Citations

May 4, 2016·Trends in Biotechnology·Ajaykumar VishwakarmaAli Khademhosseini
Jun 28, 2017·Veterinary Pathology·Mallory J DiVincenzoSamuel H Jennings
May 26, 2017·Journal of Biomedical Materials Research. Part a·Juliane PasoldRainer Bader
Sep 25, 2017·Journal of Functional Biomaterials·Elizabeth R KapasaXuebin B Yang
Jun 30, 2018·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Reinhard Elke, Claude B Rieker
Apr 13, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Stefan SchroederJan Philippe Kretzer
Oct 3, 2019·Brazilian Oral Research·Daniela Leal Zandim-BarcelosGiuseppe Alexandre Romito
Nov 7, 2019·JBJS Case Connector·Steven C van VeenJos J A M van Raaij
Sep 8, 2019·Journal of Materials Science. Materials in Medicine·I Papadimitriou-OlivgeriN A Athanasou
Sep 18, 2020·Biochemical Society Transactions·Eric MadsenDavid H Kohn
Apr 4, 2017·Foot & Ankle International·Oliver N SchipperYing Zhou
Oct 4, 2018·Clinical Oral Implants Research·Fernando Suárez-López Del AmoCristiane H Squarize
Oct 30, 2018·Journal of Orthopaedic Surgery·Spencer K WilhelmMark Karadsheh
Oct 20, 2019·International Journal of Molecular Sciences·Gaurav Kumar, Pierre-Marie Roger
Nov 14, 2017·Journal of Dental Research·T FretwurstW V Giannobile
Nov 9, 2018·International Journal of Molecular Sciences·Anika Jonitz-HeinckeMihaela R Cimpan
Jul 14, 2019·Journal of Orthopaedic Surgery and Research·Seok Woo HongHyun Sik Gong
May 23, 2018·World Journal of Orthopedics·Madhav ChowdhryEdward J McPherson
Jul 23, 2020·Journal of Biomaterials Science. Polymer Edition·Xufeng YanMin Lai
Dec 28, 2019·Journal of Clinical Medicine·Renee T OrmsbyGerald J Atkins
Oct 27, 2020·Advanced Science·Janosch SchoonSven Geissler
Jun 21, 2020·The Journal of Arthroplasty·Daniel Godoy-MonzonSantiago Svarzchtein
Mar 4, 2021·Curēus·Naga CheppalliKenneth Yaw
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Bartlomiej RadzikMathew T Mathew
Jun 28, 2021·Drug Delivery and Translational Research·Samira Aghlara-FotovatOmid Veiseh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinics in Podiatric Medicine and Surgery
Mark T R Gaden, Benjamin J Ollivere
International Journal of Immunopathology and Pharmacology
V Del BravoG Maccauro
Chirurgie; mémoires de l'Académie de chirurgie
F LanglaisT Dreano
Clinical Orthopaedics and Related Research
H C AmstutzI C Clarke
© 2021 Meta ULC. All rights reserved