Biological Response to Time-Controlled Adaptive Ventilation Depends on Acute Respiratory Distress Syndrome Etiology

Critical Care Medicine
Pedro L SilvaPatricia R M Rocco

Abstract

To compare a time-controlled adaptive ventilation strategy, set in airway pressure release ventilation mode, versus a protective mechanical ventilation strategy in pulmonary and extrapulmonary acute respiratory distress syndrome with similar mechanical impairment. Animal study. Laboratory investigation. Forty-two Wistar rats. Pulmonary acute respiratory distress syndrome and extrapulmonary acute respiratory distress syndrome were induced by instillation of Escherichia coli lipopolysaccharide intratracheally or intraperitoneally, respectively. After 24 hours, animals were randomly assigned to receive 1 hour of volume-controlled ventilation (n = 7/etiology) or time-controlled adaptive ventilation (n = 7/etiology) (tidal volume = 8 mL/kg). Time-controlled adaptive ventilation consisted of the application of continuous positive airway pressure 2 cm H2O higher than baseline respiratory system peak pressure for a time (Thigh) of 0.75-0.85 seconds. The release pressure (Plow = 0 cm H2O) was applied for a time (Tlow) of 0.11-0.18 seconds. Tlow was set to target an end-expiratory flow to peak expiratory flow ratio of 75%. Nonventilated animals (n = 7/etiology) were used for Diffuse Alveolar Damage and molecular biology markers analyses....Continue Reading

References

Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·L GattinoniA Lissoni
Oct 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·R Al-Jamal, M S Ludwig
Feb 14, 2002·Journal of Applied Physiology·Edgardo D'AngeloJoseph Milic-Emili
Aug 30, 2003·The European Respiratory Journal. Supplement·P PelosiL Gattinoni
Sep 28, 2004·Journal of Applied Physiology·Francisco S A CavalcanteBéla Suki
Jan 15, 2005·Journal of Applied Physiology·Sara L S MenezesPatricia R M Rocco
Apr 16, 2005·Journal of Applied Physiology·Gilman B AllenGary F Nieman
Mar 30, 2006·Physiological Genomics·Tamás DolinayAugustine M K Choi
Jun 16, 2007·Journal of Applied Physiology·Andrea MoriondoDaniela Negrini
Jan 16, 2008·Current Opinion in Critical Care·Patricia R M Rocco, Paolo Pelosi
May 23, 2008·Critical Care Medicine·Douglas R RivaPatricia R M Rocco
Oct 25, 2008·Journal of Applied Physiology·Christopher B MassaJason H T Bates
Dec 17, 2008·Journal of Applied Physiology·Scott P AlbertGary F Nieman
Nov 17, 2009·American Journal of Respiratory and Critical Care Medicine·Pietro CaironiLuciano Gattinoni
Jan 8, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Adi YerrapureddySusan S Margulies
Jan 5, 2011·Critical Care Medicine·Luciano GattinoniEleonora Carlesso
Feb 26, 2011·Expert Review of Respiratory Medicine·Mario PerlAlfred Ayala
May 3, 2011·American Journal of Respiratory Cell and Molecular Biology·Gustavo Matute-BelloUNKNOWN Acute Lung Injury in Animals Study Group
Jul 12, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Adrián González-LópezGuillermo M Albaiceta
Aug 30, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Esra Roan, Christopher M Waters
Oct 29, 2011·Matrix Biology : Journal of the International Society for Matrix Biology·Yvonne Hui-Fang TengPyong Woo Park
Feb 7, 2013·Critical Care : the Official Journal of the Critical Care Forum·Nawar Al-RawasAndrea Gabrielli
Nov 29, 2013·The New England Journal of Medicine·Arthur S Slutsky, V Marco Ranieri
Jun 15, 2014·Critical Care : the Official Journal of the Critical Care Forum·Cíntia Lourenco SantosPatricia Rieken Macedo Rocco
Dec 3, 2014·Journal of the American College of Surgeons·Michaela Kollisch-SinguleLouis A Gatto
Jan 31, 2015·Journal of Applied Physiology·Bradford J SmithJason H T Bates
Oct 8, 2015·JAMA Surgery·Michaela Kollisch-SinguleNader M Habashi
Dec 24, 2015·Intensive Care Medicine Experimental·Michaela Kollisch-SinguleNader M Habashi
Mar 10, 2016·American Journal of Respiratory and Critical Care Medicine·Rena BrauerPeter Chen
May 22, 2016·Intensive Care Medicine Experimental·Sumeet V JainNader M Habashi
May 25, 2016·Microscopy Research and Technique·J AdurH F Carvalho
May 2, 2017·American Journal of Respiratory and Critical Care Medicine·Eddy FanUNKNOWN American Thoracic Society, European Society of Intensive Care Medicine, and Society of Critical Care Medicine

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Citations

Jul 16, 2019·Critical Care Medicine·Nader M HabashiGary F Nieman
Jul 16, 2019·Critical Care Medicine·Eliotte L HirshbergColin K Grissom
Dec 24, 2019·Expert Review of Respiratory Medicine·Palen Mallory, Ira Cheifetz
May 26, 2018·Critical Care : the Official Journal of the Critical Care Forum·Gary F NiemanNader M Habashi
Apr 19, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Michaela Kollisch-SinguleNader M Habashi
Feb 23, 2020·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Andrew S FredericksBryan T Romito
Oct 17, 2020·Critical Care Medicine·Raquel F de MagalhãesPedro L Silva

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