Evidence suggests that previous trauma reduces the cortisol response to subsequent stressors. We examined the relation of this response to intrusive memory, and the potential moderating roles of sympathetic reactions. Pre-existing trauma-related factors and the cardiac defense response were assessed before 58 healthy participants viewed a trauma film. Salivary cortisol and alpha-amylase (sAA) were collected pre-, peri- and post-film. Intrusive memories about the film were recorded for a week. Cortisol increased whereas sAA decreased after the film. Those with more recent traumatic experiences and greater subclinical PTSD symptoms had lower cortisol concentration post-film. Lower cortisol levels predicted greater vividness of intrusions. Positive correlations between cortisol and the frequency of intrusion were only present among individuals with more sympathetic activations. These findings suggest the contribution of insufficient cortisol secretion to over-consolidation of traumatic memory, and highlight the variation attributable to individual differences and different memory characteristics.
Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement
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Measurement of dissociative states with the Clinician-Administered Dissociative States Scale (CADSS)
Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis
Initial posttraumatic urinary cortisol levels predict subsequent PTSD symptoms in motor vehicle accident victims
The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors
Glucocorticoids interact with the basolateral amygdala beta-adrenoceptor--cAMP/cAMP/PKA system in influencing memory consolidation
Injury severity, prior trauma history, urinary cortisol levels, and acute PTSD in motor vehicle accident victims
Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized study
Psychosocial stress-induced activation of salivary alpha-amylase: an indicator of sympathetic activity?
Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions
Reduced heart rate responding to trauma reliving in trauma survivors with PTSD: correlates and consequences
Do acute psychological and psychobiological responses to trauma predict subsequent symptom severities of PTSD and depression?
Salivary cortisol differs with age and sex and shows inverse associations with WHR in Swedish women: a cross-sectional study.
Neuro-psychopharmacogenetics and Neurological Antecedents of Posttraumatic Stress Disorder: Unlocking the Mysteries of Resilience and Vulnerability.
Predicting PTSD: pre-existing vulnerabilities in glucocorticoid-signaling and implications for preventive interventions
The trauma film paradigm as an experimental psychopathology model of psychological trauma: intrusive memories and beyond
Influence of the noradrenergic system on the formation of intrusive memories in women: an experimental approach with a trauma film paradigm
Visuospatial context learning and configuration learning is associated with analogue traumatic intrusions
Lower heart rate variability at baseline is associated with more consecutive intrusive memories in an experimental distressing film paradigm
The relationship between suppression and subsequent intrusions: the mediating role of peritraumatic dissociation and anxiety
Reduction in the occurrence of distressing involuntary memories following propranolol or hydrocortisone in healthy women.
The Effect of Self-Reported REM Behavior Disorder Symptomology on Intrusive Memories in Post-Traumatic Stress Disorder.
Susceptibility to others' emotions moderates immediate self-reported and biological stress responses to witnessing trauma
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