Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases.

Journal of Biomedicine & Biotechnology
Toshihiro Masaki, K Matsumura

Abstract

Dystroglycan is a central component of the dystrophin-glycoprotein complex (DGC) that links extracellular matrix with cytoskeleton, expressed in a variety of fetal and adult tissues. Dystroglycan plays diverse roles in development and homeostasis including basement membrane formation, epithelial morphogenesis, membrane stability, cell polarization, and cell migration. In this paper, we will focus on biological role of dystroglycan in Schwann cell function, especially myelination. First, we review the molecular architecture of DGC in Schwann cell abaxonal membrane. Then, we will review the loss-of-function studies using targeted mutagenesis, which have revealed biological functions of each component of DGC in Schwann cells. Based on these findings, roles of dystroglycan in Schwann cell function, in myelination in particular, and its implications in diseases will be discussed in detail. Finally, in view of the fact that understanding the role of dystroglycan in Schwann cells is just beginning, future perspectives will be discussed.

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Citations

Jul 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diane L ShermanPeter J Brophy
Jan 18, 2013·ISRN Neurology·Toshihiro Masaki
May 26, 2012·Trends in Neurosciences·Adrian WaiteDerek J Blake
May 21, 2011·Gene·Albert Mulenga, Kelly Erikson
Aug 18, 2016·Progress in Neurobiology·Maria Egle De Stefano, Maria Trinidad Herrero
May 4, 2017·Journal of Cellular Physiology·Hina F BhatNazir A Ganai
Jul 28, 2018·Pathogens and Disease·Héctor Serrano-CollNora Cardona-Castro
Aug 24, 2018·Neural Regeneration Research·Sheng YiLing-Yan Xing
Nov 5, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Anoohya N MuppiralaSarah C Petersen
Aug 8, 2021·International Journal of Molecular Sciences·Shama R IyerRichard M Lovering

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Methods Mentioned

BETA
transgenic
Glycosylation
GTPase
biopsy
two hybrid
histone acetylation

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