Biological role of mannose binding lectin: From newborns to centenarians

Clinica Chimica Acta; International Journal of Clinical Chemistry
Manuela ScorzaGiuseppe Castaldo

Abstract

Mannose binding lectin (MBL) is a protein of innate immunity that activates the complement and promotes opsonophagocytosis. The deficiency of MBL due to several common gene polymorphisms significantly enhances the risk of severe infections, particularly in the neonatal age and in childhood. On the contrary, the role of the protein in carcinogenesis and atherogenesis is still debated: MBL has a relevant role against neoplastic cells, but some studies described a protective effect of low levels of MBL toward breast cancer and a longer survival of lung cancer patients with a reduced MBL activity. Similarly, some studies concluded on the protective role of low levels of MBL toward cardiovascular diseases while other focused on a higher risk of myocardial infarction in subjects with a deficient activity of the protein. More recently, a role of MBL in the clearance of senescent cells emerged, and a study in two large cohorts of centenarians demonstrated that a high biological activity of the protein enhances the risk of autoimmune diseases. This body of data strongly suggests that the optimal levels of MBL activity depend on the age and on the environmental context of each subject.

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Citations

Nov 4, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wei YuWei Shen
Jan 23, 2016·Acta Neurologica Scandinavica·J-Y CaiZ-Q Yu
Jul 12, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·D NasioudisS S Witkin
Jun 27, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J Lombardo-QuezadaM Navasa
May 3, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Paolo Maria MatricardiRoberto Nisini
Aug 8, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Michael P SchönKerstin Steinbrink
Sep 4, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Michael P SchönKerstin Steinbrink

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