Biological role of miR-204 and miR-211 in melanoma

Oncoscience
Marianna VitielloLaura Poliseno

Abstract

In this short report, we pinpoint some technical and conceptual flaws that we found in the article entitled "miR-204-5p and miR-211-5p contribute to BRAF inhibitor resistance in melanoma" (Díaz-Martínez et al., Cancer Research 2018). We also discuss how, in our opinion, these flaws led Díaz-Martínez and colleagues to incorrect conclusions about the biological role that miR-204 and miR-211 play in melanoma and about the terms of their involvement in the phenomenon of resistance to BRAF inhibitors.

References

Mar 13, 2013·Cancer Cell·Rizwan HaqHans R Widlund
Feb 10, 2017·Nature Communications·Isabella S KimRichard M White
Dec 13, 2017·Cancer Research·Marta Díaz-MartínezJoaquin Teixidó
Mar 11, 2018·Molecular Cancer·Marco GalassoStefano Volinia

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Citations

Feb 6, 2020·International Journal of Molecular Sciences·Francesca Varrone, Emilia Caputo
Oct 11, 2020·Biology Open·Samanta SartiLaura Poliseno

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Datasets Mentioned

BETA
GSE107576
GSE94423

Methods Mentioned

BETA
RNA-seq

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