Biological Roles Played by Sphingolipids in Dimorphic and Filamentous Fungi

MBio
Caroline Mota FernandesMaurizio Del Poeta

Abstract

Filamentous and dimorphic fungi cause invasive mycoses associated with high mortality rates. Among the fungal determinants involved in the establishment of infection, glycosphingolipids (GSLs) have gained increased interest in the last few decades. GSLs are ubiquitous membrane components that have been isolated from both filamentous and dimorphic species and play a crucial role in polarized growth as well as hypha-to-yeast transition. In fungi, two major classes of GSLs are found: neutral and acidic GSLs. Neutral GSLs comprise glucosylceramide and galactosylceramide, which utilize Δ4-Δ8-9-methyl-sphingadienine as a sphingoid base, linked to a C16-18 fatty acid chain, forming ceramide, and to a sugar residue, such as glucose or galactose. In contrast, acidic GSLs include glycosylinositol phosphorylceramides (GIPCs), composed of phytosphingosine attached to a long or very long fatty acid chain (C18-26) and to diverse and complex glycan groups via an inositol-phosphate linker. GIPCs are absent in mammalian cells, while fungal glucosylceramide and galactosylceramide are present but diverge structurally from their counterparts. Therefore, these compounds and their biosynthetic pathways represent potential targets for the development...Continue Reading

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Citations

Jul 17, 2020·Expert Review of Anti-infective Therapy·Caroline Mota Fernandes, Maurizio Del Poeta
Aug 9, 2020·Molecular Microbiology·Jinxing SongRongpeng Li
Jan 30, 2019·Frontiers in Microbiology·João Henrique Tadini Marilhano FabriIran Malavazi
Jun 18, 2020·MBio·Hannah E BrownJ Andrew Alspaugh
May 21, 2019·Frontiers in Microbiology·Diego O HartmannCristina Silva Pereira
Dec 24, 2019·Frontiers in Cell and Developmental Biology·Johannes M F G AertsR G Boot
Jan 10, 2020·Future Science OA·Ryuichi MashimaMari Ohira
Jul 24, 2020·Rapid Communications in Mass Spectrometry : RCM·Kofo SaromiGerald Larrouy-Maumus
Nov 25, 2020·Antimicrobial Agents and Chemotherapy·Caroline Mota FernandesMaurizio Del Poeta
Sep 6, 2020·Progress in Lipid Research·João Henrique Tadini Marilhano FabriMaurizio Del Poeta
Jun 22, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Xin WangJingyu Zhu

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Methods Mentioned

BETA
phylogenetic profiling

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