Biological Significance of Local TGF-β Activation in Liver Diseases.

Frontiers in Physiology
Hiromitsu Hayashi, Takao Sakai

Abstract

The cytokine transforming growth factor-β (TGF-β) plays a pivotal role in a diverse range of cellular responses, including cell proliferation, apoptosis, differentiation, migration, adhesion, angiogenesis, stimulation of extracellular matrix (ECM) synthesis, and downregulation of ECM degradation. TGF-β and its receptors are ubiquitously expressed by most cell types and tissues in vivo. In intact adult tissues and organs, TGF-β is secreted in a biologically inactive (latent) form associated in a non-covalent complex with the ECM. In response to injury, local latent TGF-β complexes are converted into active TGF-β according to a tissue- and injury type-specific activation mechanism. Such a well and tightly orchestrated regulation in TGF-β activity enables an immediate, highly localized response to type-specific tissue injury. In the pathological process of liver fibrosis, TGF-β plays as a master profibrogenic cytokine in promoting activation and myofibroblastic differentiation of hepatic stellate cells, a central event in liver fibrogenesis. Continuous and/or persistent TGF-β signaling induces sustained production of ECM components and of tissue inhibitor of metalloproteinase synthesis. Therefore, the regulation of locally activat...Continue Reading

Citations

Mar 5, 2016·Frontiers in Pharmacology·Hans-Theo SchonRalf Weiskirchen
Dec 17, 2014·Periodontology 2000·Patricio C SmithJorge Martínez
Jun 18, 2014·Biochimica Et Biophysica Acta·Valentina MasolaMaurizio Onisto
May 20, 2015·Nature Cell Biology·Bruno Costa-SilvaDavid Lyden
May 23, 2015·Science Translational Medicine·Harry C Dietz
Nov 2, 2016·BioMed Research International·Takaoki SaneyasuTakao Sakai
Aug 20, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiromitsu HayashiHideo Baba
Nov 9, 2016·Frontiers in Physiology·Jiří Kanta
Dec 17, 2016·Cancer Gene Therapy·R NedaeiniaM Ghayour-Mobarhan
Feb 9, 2017·The Korean Journal of Internal Medicine·Young Kul Jung, Hyung Joon Yim
Nov 18, 2016·Scientific Reports·Anaïs BisonRosa-Maria Guéant-Rodriguez
Feb 28, 2013·International Journal of Cancer. Journal International Du Cancer·Izza de Arao TanDarryl L Russell
Apr 30, 2016·The European Respiratory Journal·Irene H HeijinkDirkje S Postma
Jan 7, 2014·Alimentary Pharmacology & Therapeutics·A J Czaja
Oct 31, 2019·Neuroscience Bulletin·Yurong ZhangHongliu Sun
Feb 15, 2020·Journal of Receptor and Signal Transduction Research·Bhagyalakshmi Nair, Lekshmi R Nath
Jan 22, 2015·Exercise and Sport Sciences Reviews·Jonathan P GumucioChristopher L Mendias
Sep 17, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoriko NomuraHirohisa Yano
Dec 6, 2017·Molecular Medicine Reports·Zhenguo LiuXuegong Fan
Aug 24, 2019·Cancers·Nicholas F Brown, John F Marshall
Aug 17, 2020·Animals : an Open Access Journal From MDPI·Zhe ZhangJia-Bao Zhang
Oct 19, 2016·Digestive Diseases and Sciences·Aldo J Montano-LozaAlbert J Czaja
Jul 15, 2017·World Journal of Gastroenterology : WJG·Erika Hernández-AquinoPablo Muriel
Jul 22, 2017·Molecular Medicine Reports·Shinsaku YamaguchiKen-Ichi Matsumoto
Dec 1, 2018·Mediators of Inflammation·Amal Ahmed Abd El-FattahAmal Mohamed Kamal
Dec 18, 2019·Cells·Joanna BoguslawskaAgnieszka Piekielko-Witkowska
Feb 15, 2020·The Journal of Poultry Science·Takaoki SaneyasuHiroshi Kamisoyama
Oct 3, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shinichiro YamadaMitsuo Shimada
Jan 30, 2016·European Journal of Clinical Investigation·Gianluigi GiannelliAranzazu Sanchez
May 26, 2018·International Journal of Molecular Sciences·Hendrik UngefrorenBernhard H Rauch
Oct 20, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Erika Ramos-TovarPablo Muriel
Dec 4, 2020·International Journal of Molecular Sciences·Xianglan ZhangEunae Sandra Cho
Dec 22, 2020·Frontiers in Pharmacology·Linshen Xie, Ye Zeng
Mar 17, 2020·Matrix Biology : Journal of the International Society for Matrix Biology·Mahbubul H ShihanMelinda K Duncan

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