PMID: 8582339Sep 1, 1995Paper

Biological significance of minisatellites

Electrophoresis
L Singh

Abstract

Minisatellites are tandemly repeated, highly variable DNA sequences found in most higher eukaryotes. These contain a core sequence resembling the chi sequence of Escherichia coli, which is a binding site for recombination proteins. Based on this, a generalized function of minisatellites to provide binding sites for recombination proteins in eukaryotes has also been suggested. However, recent discoveries of trinucleotide repeat expansion mutations associated with at least four human genetic diseases, several short repeats acting as motifs for binding of various transcription factors, and several minisatellite-binding nuclear proteins, which are expressed in specific tissues and bind to specific sequences, strongly suggest that different families of minisatellites may have different functions. A banded krait minor (Bkm) satellite DNA, consisting of highly conserved GATA repeats, which is arranged in a sex-specific manner, is hypervariable. We have found a sex- and tissue-specific factor designated as Bkm-binding protein (BBP), which specifically binds to Bkm (GATA), in the germ cells of the heterogametic sex [ovary, in the case of female heterogamety (in snakes); and testis, in the case of male heterogamety (in mice, rats and hum...Continue Reading

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Citations

Sep 1, 1995·Electrophoresis·E M Southern
Feb 12, 1998·Electrophoresis·P G Righetti, C Gelfi
Nov 1, 2002·Biochemical and Biophysical Research Communications·Donald E Riley, John N Krieger
Apr 27, 2001·Biochemical and Biophysical Research Communications·K Shanti, M S Kanungo
Apr 2, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Donald E Riley, John N Krieger

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