Biological tests carried out on serum/plasma samples from donors of human body material for transplantation: Belgian experience and practical recommendations

Cell and Tissue Banking
Elizaveta PadalkoHilde Beele

Abstract

This paper on the biological tests carried out on serum/plasma samples from donors of human body material (HBM) is the result of a project of the working Group of Superior Health Council of Belgium formed with experts in the field of HBM and infectious serology. Indeed, uncertainty about the interpretation of biological test results currently leads to the sometimes unjustified cancelling of planned donations or the rejection of harvested HBM, whilst more sophisticated diagnostic algorithms would still allow the use of organs or HBM that would otherwise have been rejected. NAT tests will not be discussed in this publication. In the first part some general aspects as the need for a formal agreement between the Tissue Establishment l and the laboratory responsible for the biological testing, but also some specifications regarding testing material, the choice of additional biological tests, and some general aspects concerning interpretation and reporting are discussed. In a second part, detailed information and recommendations concerning the interpretation are presented for each of the mandatory tests (human immunodeficiency virus, hepatitis B virus, hepatitis C virus and syphilis) is presented. A number of not mandatory, but regul...Continue Reading

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Citations

Dec 19, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Vandita DwivediMichal Sharon
Jul 16, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Brecht ValckeWouter Willaert

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Methods Mentioned

BETA
blood collection
Infection

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